TY - JOUR
T1 - Gaps in biomedical research in frontotemporal dementia
T2 - A call for diversity and disparities focused research
AU - Nuytemans, Karen
AU - Franzen, Sanne
AU - Broce, Iris J.
AU - Caramelli, Paulo
AU - Ellajosyula, Ratnavalli
AU - Finger, Elizabeth
AU - Gupta, Veer
AU - Gupta, Vivek
AU - Illán-Gala, Ignacio
AU - Loi, Samantha M.
AU - Morhardt, Darby
AU - Pijnenburg, Yolande
AU - Rascovsky, Katya
AU - Williams, Monique M.
AU - Yokoyama, Jennifer S.
AU - Acosta-Uribe, Juliana
AU - Akinyemi, Rufus
AU - Alladi, Suvarna
AU - Ayele, Biniyam A.
AU - Ayhan, Yavuz
AU - Bourdage, Renelle
AU - Castro-Suarez, Sheila
AU - de Souza, Leonardo Cruz
AU - Dacks, Penny
AU - de Boer, Sterre C. M.
AU - de Leon, Jessica
AU - Dodge, Shana
AU - Grasso, Stephanie
AU - Ghoshal, Nupur
AU - Kamath, Vidyulata
AU - Kumfor, Fiona
AU - Matias-Guiu, Jordi A.
AU - Narme, Pauline
AU - Nielsen, T. Rune
AU - Okhuevbie, Daniel
AU - Piña-Escudero, Stefanie
AU - Ruiz-Garcia, Ramiro
AU - Ryan, Brigid
AU - Scarioni, Marta
AU - Slachevsky, Andrea
AU - Suarez-Gonzalez, Aida
AU - Tee, Boon Lead
AU - Tsoy, Elena
AU - Ulugut, Hulya
AU - Onyike, Chiadi U.
AU - ISTAART Frontotemporal Dementia and Related Disorders PIA, ISTAART Diversity and Disparities PIA
AU - Babulal, Ganesh M.
N1 - Publisher Copyright:
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2024/12
Y1 - 2024/12
N2 - Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
AB - Frontotemporal dementia (FTD) is one of the leading causes of young-onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross-cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.
KW - biomarkers
KW - cultural diversity
KW - epidemiology
KW - ethnicity
KW - frontotemporal dementia
KW - genetics
KW - infrastructure
UR - https://www.scopus.com/pages/publications/85209074205
U2 - 10.1002/alz.14312
DO - 10.1002/alz.14312
M3 - Article
C2 - 39535468
SN - 1552-5260
VL - 20
SP - 9014
EP - 9036
JO - Alzheimer s & dementia
JF - Alzheimer s & dementia
IS - 12
ER -