Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence

Matthew Randesi; Orna Levran; Wim van den Brink; Peter Blanken; Jan M. van Ree; Jurg Ott; Mary J. Kreek

doi:10.2217/pgs-2020-0045

Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence

Matthew Randesi^*
, Orna Levran
, Wim van den Brink
, Peter Blanken
, Jan M. van Ree
, Jurg Ott
, Mary J. Kreek

^*Corresponding author for this work

Rockefeller University
Parnassia Addiction Research Centre (Brijder Addiction Treatment)
University Medical Center Utrecht

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

Original language	English
Pages (from-to)	903-917
Journal	Pharmacogenomics
Volume	21
Issue number	13
DOIs	https://doi.org/10.2217/pgs-2020-0045
Publication status	Published - 1 Aug 2020

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SDG 3 Good Health and Well-being

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10.2217/pgs-2020-0045

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title = "Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence",

abstract = "Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients \& methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.",

author = "Matthew Randesi and Orna Levran and \{van den Brink\}, Wim and Peter Blanken and \{van Ree\}, \{Jan M.\} and Jurg Ott and Kreek, \{Mary J.\}",

year = "2020",

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doi = "10.2217/pgs-2020-0045",

language = "English",

volume = "21",

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journal = "Pharmacogenomics",

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}

TY - JOUR

T1 - Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence

AU - Randesi, Matthew

AU - Levran, Orna

AU - van den Brink, Wim

AU - Blanken, Peter

AU - van Ree, Jan M.

AU - Ott, Jurg

AU - Kreek, Mary J.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

AB - Aim: Heroin addiction is a chronic, relapsing disease that has genetic and environmental, including drug-induced, contributions. Stress influences the development of addictions. This study was conducted to determine if variants in stress-related genes are associated with opioid dependence (OD). Patients & methods: One hundred and twenty variants in 26 genes were analyzed in 597 Dutch subjects. Patients included 281 OD in methadone maintenance with or without heroin-assisted treatment and 316 controls. Results: Twelve SNPs in seven genes showed a nominally significant association with OD. Experiment-wise significant associations (p < 0.05) were found for three SNP pairs, through an interaction effect: NPY1R/GAL rs4691910/rs1893679, NPY1R/GAL rs4691910/rs3136541 and GALR1/GAL rs9807208/rs3136541. Conclusion: This study lends more evidence to previous reports of association of stress-related variants with heroin dependence.

UR - https://www.scopus.com/pages/publications/85090870542

UR - https://www.ncbi.nlm.nih.gov/pubmed/32757697

U2 - 10.2217/pgs-2020-0045

DO - 10.2217/pgs-2020-0045

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C2 - 32757697

SN - 1462-2416

VL - 21

SP - 903

EP - 917

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 13

ER -

Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence

Abstract

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