Fulminant falciparum malaria

W. M. Smit; H. M. Oudemans-van Straaten; D. F. Zandstra

doi:10.1007/BF01709404

Fulminant falciparum malaria

W. M. Smit^*
, H. M. Oudemans-van Straaten
, D. F. Zandstra

^*Corresponding author for this work

Onze Lieve Vrouwe Gasthui

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

A case of fulminant falciparum malaria with a 35% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. Pathophysiology and complications of falciparum malaria are discussed. The treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. An exchange transfusion can be additive to parenteral chemotherapy. Blocking the over-reacting cell-mediated immune response, aggressive shock treatment, prevention of secondary infections and maintaining normoglycaemia might reduce morbidity and mortality of fulminant falciparum malaria.

Original language	English
Pages (from-to)	517-519
Number of pages	3
Journal	Intensive care medicine
Volume	16
Issue number	8
DOIs	https://doi.org/10.1007/BF01709404
Publication status	Published - 1 Aug 1990

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Corticosteroids
Exchange transfusion
Malaria
Tumour necrosis factor

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10.1007/BF01709404

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title = "Fulminant falciparum malaria",

abstract = "A case of fulminant falciparum malaria with a 35\% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. Pathophysiology and complications of falciparum malaria are discussed. The treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. An exchange transfusion can be additive to parenteral chemotherapy. Blocking the over-reacting cell-mediated immune response, aggressive shock treatment, prevention of secondary infections and maintaining normoglycaemia might reduce morbidity and mortality of fulminant falciparum malaria.",

keywords = "Corticosteroids, Exchange transfusion, Malaria, Tumour necrosis factor",

author = "Smit, \{W. M.\} and \{Oudemans-van Straaten\}, \{H. M.\} and Zandstra, \{D. F.\}",

year = "1990",

month = aug,

day = "1",

doi = "10.1007/BF01709404",

language = "English",

volume = "16",

pages = "517--519",

journal = "Intensive care medicine",

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TY - JOUR

T1 - Fulminant falciparum malaria

AU - Smit, W. M.

AU - Oudemans-van Straaten, H. M.

AU - Zandstra, D. F.

PY - 1990/8/1

Y1 - 1990/8/1

N2 - A case of fulminant falciparum malaria with a 35% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. Pathophysiology and complications of falciparum malaria are discussed. The treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. An exchange transfusion can be additive to parenteral chemotherapy. Blocking the over-reacting cell-mediated immune response, aggressive shock treatment, prevention of secondary infections and maintaining normoglycaemia might reduce morbidity and mortality of fulminant falciparum malaria.

AB - A case of fulminant falciparum malaria with a 35% parasitaemia, shock and subcoma was treated successfully by using parenteral chemotherapy, exchange transfusion, dexamethasone, circulatory support and mechanical ventilation. Pathophysiology and complications of falciparum malaria are discussed. The treatment of severe malaria should aim for a fast reduction in parasitaemia and toxic products. An exchange transfusion can be additive to parenteral chemotherapy. Blocking the over-reacting cell-mediated immune response, aggressive shock treatment, prevention of secondary infections and maintaining normoglycaemia might reduce morbidity and mortality of fulminant falciparum malaria.

KW - Corticosteroids

KW - Exchange transfusion

KW - Malaria

KW - Tumour necrosis factor

UR - https://www.scopus.com/pages/publications/0025634436

U2 - 10.1007/BF01709404

DO - 10.1007/BF01709404

M3 - Article

C2 - 2286734

SN - 0342-4642

VL - 16

SP - 517

EP - 519

JO - Intensive care medicine

JF - Intensive care medicine

IS - 8

ER -

Fulminant falciparum malaria

Abstract

UN SDGs

Keywords

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