TY - JOUR
T1 - Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
AU - AUTHOR GROUP
AU - Ikram, M. Kamran
AU - Sim, Xueling
AU - Xueling, Sim
AU - Jensen, Richard A.
AU - Cotch, Mary Frances
AU - Hewitt, Alex W.
AU - Ikram, M. Arfan
AU - Wang, Jie Jin
AU - Klein, Ronald
AU - Klein, Barbara E. K.
AU - Breteler, Monique M. B.
AU - Cheung, Ning
AU - Liew, Gerald
AU - Mitchell, Paul
AU - Uitterlinden, Andre G.
AU - Rivadeneira, Fernando
AU - Hofman, Albert
AU - de Jong, Paulus T. V. M.
AU - van Duijn, Cornelia M.
AU - Kao, Linda
AU - Cheng, Ching-Yu
AU - Smith, Albert Vernon
AU - Glazer, Nicole L.
AU - Lumley, Thomas
AU - McKnight, Barbara
AU - Psaty, Bruce M.
AU - Jonasson, Fridbert
AU - Eiriksdottir, Gudny
AU - Aspelund, Thor
AU - Harris, Tamara B.
AU - Launer, Lenore J.
AU - Taylor, Kent D.
AU - Li, Xiaohui
AU - Iyengar, Sudha K.
AU - Xi, Quansheng
AU - Sivakumaran, Theru A.
AU - Mackey, David A.
AU - Macgregor, Stuart
AU - Martin, Nicholas G.
AU - Young, Terri L.
AU - Bis, Josh C.
AU - Wiggins, Kerri L.
AU - Heckbert, Susan R.
AU - Hammond, Christopher J.
AU - Andrew, Toby
AU - Fahy, Samantha
AU - Attia, John
AU - Holliday, Elizabeth G.
AU - Scott, Rodney J.
AU - Islam, F. M. Amirul
PY - 2010
Y1 - 2010
N2 - There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p <5.0×10(-8)) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.61×10(-25), within the RASIP1 locus), rs225717 (6q24; p = 1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p = 2.15×10(-13), in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.32×10(-16), adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease
AB - There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p <5.0×10(-8)) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.61×10(-25), within the RASIP1 locus), rs225717 (6q24; p = 1.25×10(-16), adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p = 2.15×10(-13), in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.32×10(-16), adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease
U2 - 10.1371/journal.pgen.1001184
DO - 10.1371/journal.pgen.1001184
M3 - Article
C2 - 21060863
SN - 1553-7390
VL - 6
SP - e1001184
JO - PLoS genetics
JF - PLoS genetics
IS - 10
ER -
SDG 3 Good Health and Well-being