Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications

H Lu; R J Bekker; M J Grundeken; P Woudstra; J J Wykrzykowska; J G P Tijssen; R J de Winter; K T Koch

doi:10.1007/s12471-018-1111-7

Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications

H Lu
, R J Bekker
, M J Grundeken
, P Woudstra
, J J Wykrzykowska
, J G P Tijssen
, R J de Winter
, K T Koch

Department of cardiology
Academic Medical Center
University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVES: We sought to investigate angiographic indications for the use of the STENTYS technique and evaluated the long-term safety and clinical efficacy of the stent.

BACKGROUND: Coronary lesions involving complex anatomy, including aneurysmatic, ectatic, or tapered vessel segments often carry a substantial risk of stent malapposition. The self-apposing stent technique may reduce the risk of stent malapposition and therefore improve clinical outcomes.

METHODS: A total of 120 consecutive patients treated with the STENTYS stent were included (drug-eluting stent (DES) n = 101, bare-metal stent (BMS) n = 19). All lesions were scored for angiographic indications for the STENTYS stent, including aneurysms, ectasias, tapering, absolute diameters, bifurcation lesions, and saphenous vein grafts. Off-line quantitative coronary angiography analyses were performed pre-procedure and post-procedure. Five years follow-up was obtained including cardiac death, target vessel myocardial infarction (TV-MI), target vessel revascularisation, stent thrombosis, and the composite endpoint target vessel failure (cardiac death, TV-MI and target vessel revascularisation).

RESULTS: Angiographic indications for STENTYS use were aneurysm (30%), ectasia (19%), tapering (27%), bifurcation lesions (8%), and saphenous vein graft lesions (16%) and absolute diameters (22%). Mean maximal diameter was 4.51 ± 0.99 mm. At 5‑year follow-up target vessel failure rates were 24.1% in the total cohort (DES 22.8% vs. BMS 33%, p = 0.26). Definite stent thrombosis rate was 3.8% at 5‑year follow-up in this cohort with complex and high-risk lesions (DES 4.5% vs. BMS 0%, p = 0.39).

CONCLUSIONS: Angiographic indications for the use of the self-apposing stent were complex lesions with atypical coronary anatomy. Our data showed reasonable stent thrombosis rates at 5‑year follow-up, considering the high-risk lesion characteristics.

Original language	English
Pages (from-to)	263-271
Number of pages	9
Journal	Netherlands Heart Journal
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s12471-018-1111-7
Publication status	Published - May 2018

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Lu, H., Bekker, R. J., Grundeken, M. J., Woudstra, P., Wykrzykowska, J. J., Tijssen, J. G. P., de Winter, R. J., & Koch, K. T. (2018). Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications. Netherlands Heart Journal, 26(5), 263-271. https://doi.org/10.1007/s12471-018-1111-7

@article{8ff781a2abea4633972f26ae56b710c7,

title = "Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications",

abstract = "OBJECTIVES: We sought to investigate angiographic indications for the use of the STENTYS technique and evaluated the long-term safety and clinical efficacy of the stent.BACKGROUND: Coronary lesions involving complex anatomy, including aneurysmatic, ectatic, or tapered vessel segments often carry a substantial risk of stent malapposition. The self-apposing stent technique may reduce the risk of stent malapposition and therefore improve clinical outcomes.METHODS: A total of 120 consecutive patients treated with the STENTYS stent were included (drug-eluting stent (DES) n = 101, bare-metal stent (BMS) n = 19). All lesions were scored for angiographic indications for the STENTYS stent, including aneurysms, ectasias, tapering, absolute diameters, bifurcation lesions, and saphenous vein grafts. Off-line quantitative coronary angiography analyses were performed pre-procedure and post-procedure. Five years follow-up was obtained including cardiac death, target vessel myocardial infarction (TV-MI), target vessel revascularisation, stent thrombosis, and the composite endpoint target vessel failure (cardiac death, TV-MI and target vessel revascularisation).RESULTS: Angiographic indications for STENTYS use were aneurysm (30\%), ectasia (19\%), tapering (27\%), bifurcation lesions (8\%), and saphenous vein graft lesions (16\%) and absolute diameters (22\%). Mean maximal diameter was 4.51 ± 0.99 mm. At 5‑year follow-up target vessel failure rates were 24.1\% in the total cohort (DES 22.8\% vs. BMS 33\%, p = 0.26). Definite stent thrombosis rate was 3.8\% at 5‑year follow-up in this cohort with complex and high-risk lesions (DES 4.5\% vs. BMS 0\%, p = 0.39).CONCLUSIONS: Angiographic indications for the use of the self-apposing stent were complex lesions with atypical coronary anatomy. Our data showed reasonable stent thrombosis rates at 5‑year follow-up, considering the high-risk lesion characteristics.",

author = "H Lu and Bekker, \{R J\} and Grundeken, \{M J\} and P Woudstra and Wykrzykowska, \{J J\} and Tijssen, \{J G P\} and \{de Winter\}, \{R J\} and Koch, \{K T\}",

year = "2018",

month = may,

doi = "10.1007/s12471-018-1111-7",

language = "English",

volume = "26",

pages = "263--271",

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}

Lu, H, Bekker, RJ, Grundeken, MJ, Woudstra, P, Wykrzykowska, JJ, Tijssen, JGP , de Winter, RJ & Koch, KT 2018, 'Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications', Netherlands Heart Journal, vol. 26, no. 5, pp. 263-271. https://doi.org/10.1007/s12471-018-1111-7

TY - JOUR

T1 - Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy

T2 - a single-centre experience with report of specific angiographic indications

AU - Lu, H

AU - Bekker, R J

AU - Grundeken, M J

AU - Woudstra, P

AU - Wykrzykowska, J J

AU - Tijssen, J G P

AU - de Winter, R J

AU - Koch, K T

PY - 2018/5

Y1 - 2018/5

N2 - OBJECTIVES: We sought to investigate angiographic indications for the use of the STENTYS technique and evaluated the long-term safety and clinical efficacy of the stent.BACKGROUND: Coronary lesions involving complex anatomy, including aneurysmatic, ectatic, or tapered vessel segments often carry a substantial risk of stent malapposition. The self-apposing stent technique may reduce the risk of stent malapposition and therefore improve clinical outcomes.METHODS: A total of 120 consecutive patients treated with the STENTYS stent were included (drug-eluting stent (DES) n = 101, bare-metal stent (BMS) n = 19). All lesions were scored for angiographic indications for the STENTYS stent, including aneurysms, ectasias, tapering, absolute diameters, bifurcation lesions, and saphenous vein grafts. Off-line quantitative coronary angiography analyses were performed pre-procedure and post-procedure. Five years follow-up was obtained including cardiac death, target vessel myocardial infarction (TV-MI), target vessel revascularisation, stent thrombosis, and the composite endpoint target vessel failure (cardiac death, TV-MI and target vessel revascularisation).RESULTS: Angiographic indications for STENTYS use were aneurysm (30%), ectasia (19%), tapering (27%), bifurcation lesions (8%), and saphenous vein graft lesions (16%) and absolute diameters (22%). Mean maximal diameter was 4.51 ± 0.99 mm. At 5‑year follow-up target vessel failure rates were 24.1% in the total cohort (DES 22.8% vs. BMS 33%, p = 0.26). Definite stent thrombosis rate was 3.8% at 5‑year follow-up in this cohort with complex and high-risk lesions (DES 4.5% vs. BMS 0%, p = 0.39).CONCLUSIONS: Angiographic indications for the use of the self-apposing stent were complex lesions with atypical coronary anatomy. Our data showed reasonable stent thrombosis rates at 5‑year follow-up, considering the high-risk lesion characteristics.

AB - OBJECTIVES: We sought to investigate angiographic indications for the use of the STENTYS technique and evaluated the long-term safety and clinical efficacy of the stent.BACKGROUND: Coronary lesions involving complex anatomy, including aneurysmatic, ectatic, or tapered vessel segments often carry a substantial risk of stent malapposition. The self-apposing stent technique may reduce the risk of stent malapposition and therefore improve clinical outcomes.METHODS: A total of 120 consecutive patients treated with the STENTYS stent were included (drug-eluting stent (DES) n = 101, bare-metal stent (BMS) n = 19). All lesions were scored for angiographic indications for the STENTYS stent, including aneurysms, ectasias, tapering, absolute diameters, bifurcation lesions, and saphenous vein grafts. Off-line quantitative coronary angiography analyses were performed pre-procedure and post-procedure. Five years follow-up was obtained including cardiac death, target vessel myocardial infarction (TV-MI), target vessel revascularisation, stent thrombosis, and the composite endpoint target vessel failure (cardiac death, TV-MI and target vessel revascularisation).RESULTS: Angiographic indications for STENTYS use were aneurysm (30%), ectasia (19%), tapering (27%), bifurcation lesions (8%), and saphenous vein graft lesions (16%) and absolute diameters (22%). Mean maximal diameter was 4.51 ± 0.99 mm. At 5‑year follow-up target vessel failure rates were 24.1% in the total cohort (DES 22.8% vs. BMS 33%, p = 0.26). Definite stent thrombosis rate was 3.8% at 5‑year follow-up in this cohort with complex and high-risk lesions (DES 4.5% vs. BMS 0%, p = 0.39).CONCLUSIONS: Angiographic indications for the use of the self-apposing stent were complex lesions with atypical coronary anatomy. Our data showed reasonable stent thrombosis rates at 5‑year follow-up, considering the high-risk lesion characteristics.

UR - https://www.scopus.com/pages/publications/85060335231

UR - https://www.ncbi.nlm.nih.gov/pubmed/29654515

U2 - 10.1007/s12471-018-1111-7

DO - 10.1007/s12471-018-1111-7

M3 - Article

C2 - 29654515

SN - 1568-5888

VL - 26

SP - 263

EP - 271

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 5

ER -

Five-year clinical follow-up of the STENTYS self-apposing stent in complex coronary anatomy: a single-centre experience with report of specific angiographic indications

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