Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism

Meindert Palmen; Mat J. A. P. Daemen; Leon J. de Windt; Jodil Willems; Willem R. M. Dassen; Sylvia Heeneman; Rene Zimmermann; Marc van Bilsen; Pieter A. Doevendans

doi:10.1016/j.jacc.2004.05.067

Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism

Meindert Palmen
, Mat J. A. P. Daemen
, Leon J. de Windt
, Jodil Willems
, Willem R. M. Dassen
, Sylvia Heeneman
, Rene Zimmermann
, Marc van Bilsen
, Pieter A. Doevendans

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. The FGFs display cardioprotective effects during ischemia and reperfusion. We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion. Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death. The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK

Original language	English
Pages (from-to)	1113-1123
Journal	Journal of the American College of Cardiology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1016/j.jacc.2004.05.067
Publication status	Published - 2004

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Palmen, M., Daemen, M. J. A. P., de Windt, L. J., Willems, J., Dassen, W. R. M., Heeneman, S., Zimmermann, R., van Bilsen, M., & Doevendans, P. A. (2004). Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. Journal of the American College of Cardiology, 44(5), 1113-1123. https://doi.org/10.1016/j.jacc.2004.05.067

Palmen, Meindert ; Daemen, Mat J. A. P. ; de Windt, Leon J. et al. / Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. In: Journal of the American College of Cardiology. 2004 ; Vol. 44, No. 5. pp. 1113-1123.

@article{b601dafeb5ba42a9a4c5504804385b33,

title = "Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism",

abstract = "We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. The FGFs display cardioprotective effects during ischemia and reperfusion. We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion. Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death. The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK",

author = "Meindert Palmen and Daemen, \{Mat J. A. P.\} and \{de Windt\}, \{Leon J.\} and Jodil Willems and Dassen, \{Willem R. M.\} and Sylvia Heeneman and Rene Zimmermann and \{van Bilsen\}, Marc and Doevendans, \{Pieter A.\}",

year = "2004",

doi = "10.1016/j.jacc.2004.05.067",

language = "English",

volume = "44",

pages = "1113--1123",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier USA",

number = "5",

}

Palmen, M, Daemen, MJAP, de Windt, LJ, Willems, J, Dassen, WRM, Heeneman, S, Zimmermann, R, van Bilsen, M & Doevendans, PA 2004, 'Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism', Journal of the American College of Cardiology, vol. 44, no. 5, pp. 1113-1123. https://doi.org/10.1016/j.jacc.2004.05.067

Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. / Palmen, Meindert; Daemen, Mat J. A. P.; de Windt, Leon J. et al.
In: Journal of the American College of Cardiology, Vol. 44, No. 5, 2004, p. 1113-1123.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism

AU - Palmen, Meindert

AU - Daemen, Mat J. A. P.

AU - de Windt, Leon J.

AU - Willems, Jodil

AU - Dassen, Willem R. M.

AU - Heeneman, Sylvia

AU - Zimmermann, Rene

AU - van Bilsen, Marc

AU - Doevendans, Pieter A.

PY - 2004

Y1 - 2004

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AB - We sought to investigate the role of fibroblast growth factor (FGF)-1 during acute myocardial ischemia and reperfusion. The FGFs display cardioprotective effects during ischemia and reperfusion. We investigated FGF-1-induced cardioprotection during ischemia and reperfusion and the intracellular signaling pathways responsible for these effects in an ex vivo murine setup of myocardial ischemia and reperfusion. Cardiac-specific human FGF-1 overexpression was associated with enhanced post-ischemic hemodynamic recovery and decreased lactate dehydrogenase release during reperfusion. Inhibition of the FGF receptor, protein kinase C (PKC), and tyrosine kinase (TK) resulted in blockade of FGF-1-induced protective effects on cardiac functional recovery and cell death. The overexpression of FGF-1 induces cardioprotection through a pathway that involves the FGF receptor, PKC, and TK

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DO - 10.1016/j.jacc.2004.05.067

M3 - Article

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SN - 0735-1097

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JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

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ER -

Palmen M, Daemen MJAP, de Windt LJ, Willems J, Dassen WRM, Heeneman S et al. Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism. Journal of the American College of Cardiology. 2004;44(5):1113-1123. doi: 10.1016/j.jacc.2004.05.067