Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study

Denis Losik; Alexander Romanov; Igor Grazhdankin; Vitaly Shabanov; Dmitry Ponomarev; Igor Mikheenko; Ivan Peregudov; Alexey Filippenko; Nikolay Bondar; Lucas Boersma; Jonathan S. Steinberg

doi:10.1007/s00380-023-02236-x

Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study

Denis Losik^*
, Alexander Romanov
, Igor Grazhdankin
, Vitaly Shabanov
, Dmitry Ponomarev
, Igor Mikheenko
, Ivan Peregudov
, Alexey Filippenko
, Nikolay Bondar
, Lucas Boersma
, Jonathan S. Steinberg

^*Corresponding author for this work

Russian Ministry of Health
Federal Center of Cardiovascular Surgery
Department of Cardiology St. Antonius Hospital Nieuwegein the Netherlands
University of Rochester

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The optimal approach for prevention of cardiovascular events and reduction of bleeding in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) is still controversial. The aim of our study is to asses our single-center experience with concomitant left atrial appendage occlusion (LAAO) and percutaneous coronary intervention (PCI). 50 patients with ACS without ST elevation and history of AF were randomized after successful PCI to LAAO or conventional medical therapy. The primary endpoints were safety and length of hospitalization. The follow-up period was 30 days. The mean procedural times were 113 ± 23 min PCI + LAAO implantation and 39 ± 19 min of PCI only (p < 0.001), while mean fluoroscopy times were 18 ± 8 min and 12 ± 8 min (p < 0.001), respectively. No procedure-related complications were observed. There was no difference observed for length of hospitalization between two groups. LAAO in patients with ACS and AF undergoing PCI appears safe. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	881-888
Number of pages	8
Journal	Heart and vessels
Volume	38
Issue number	7
DOIs	https://doi.org/10.1007/s00380-023-02236-x
Publication status	Published - 1 Jul 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute coronary syndrome
Atrial fibrillation
Left atrial appendage occlusion
Percutaneous coronary intervention

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Feasibility-of-concomitant-left-atrial-appendage-closure-and-percutaneous-coronary-intervention-in-patients-with-acute-c.pdfFinal published version, 743 KBLicence: Taverne

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Losik, D., Romanov, A., Grazhdankin, I., Shabanov, V., Ponomarev, D., Mikheenko, I., Peregudov, I., Filippenko, A., Bondar, N., Boersma, L., & Steinberg, J. S. (2023). Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study. Heart and vessels, 38(7), 881-888. https://doi.org/10.1007/s00380-023-02236-x

@article{34443e1e26b7471fa1c109d9145e4287,

title = "Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study",

abstract = "The optimal approach for prevention of cardiovascular events and reduction of bleeding in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) is still controversial. The aim of our study is to asses our single-center experience with concomitant left atrial appendage occlusion (LAAO) and percutaneous coronary intervention (PCI). 50 patients with ACS without ST elevation and history of AF were randomized after successful PCI to LAAO or conventional medical therapy. The primary endpoints were safety and length of hospitalization. The follow-up period was 30 days. The mean procedural times were 113 ± 23 min PCI + LAAO implantation and 39 ± 19 min of PCI only (p < 0.001), while mean fluoroscopy times were 18 ± 8 min and 12 ± 8 min (p < 0.001), respectively. No procedure-related complications were observed. There was no difference observed for length of hospitalization between two groups. LAAO in patients with ACS and AF undergoing PCI appears safe. Graphical abstract: [Figure not available: see fulltext.]",

keywords = "Acute coronary syndrome, Atrial fibrillation, Left atrial appendage occlusion, Percutaneous coronary intervention",

author = "Denis Losik and Alexander Romanov and Igor Grazhdankin and Vitaly Shabanov and Dmitry Ponomarev and Igor Mikheenko and Ivan Peregudov and Alexey Filippenko and Nikolay Bondar and Lucas Boersma and Steinberg, \{Jonathan S.\}",

note = "Funding Information: This study was partially supported by a research grant from Boston Scientific (Investigator Sponsored Research). The funding source had no influence on the study design, data analysis and results interpretation. This study was also carried out within the state assignment of Ministry of Health of Russian Federation (№ 121031300225–8). Publisher Copyright: {\textcopyright} 2023, Springer Nature Japan KK, part of Springer Nature.",

year = "2023",

month = jul,

day = "1",

doi = "10.1007/s00380-023-02236-x",

language = "English",

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Losik, D, Romanov, A, Grazhdankin, I, Shabanov, V, Ponomarev, D, Mikheenko, I, Peregudov, I, Filippenko, A, Bondar, N, Boersma, L & Steinberg, JS 2023, 'Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study', Heart and vessels, vol. 38, no. 7, pp. 881-888. https://doi.org/10.1007/s00380-023-02236-x

Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study. / Losik, Denis; Romanov, Alexander; Grazhdankin, Igor et al.
In: Heart and vessels, Vol. 38, No. 7, 01.07.2023, p. 881-888.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation

T2 - a randomized pilot study

AU - Losik, Denis

AU - Romanov, Alexander

AU - Grazhdankin, Igor

AU - Shabanov, Vitaly

AU - Ponomarev, Dmitry

AU - Mikheenko, Igor

AU - Peregudov, Ivan

AU - Filippenko, Alexey

AU - Bondar, Nikolay

AU - Boersma, Lucas

AU - Steinberg, Jonathan S.

N1 - Funding Information: This study was partially supported by a research grant from Boston Scientific (Investigator Sponsored Research). The funding source had no influence on the study design, data analysis and results interpretation. This study was also carried out within the state assignment of Ministry of Health of Russian Federation (№ 121031300225–8). Publisher Copyright: © 2023, Springer Nature Japan KK, part of Springer Nature.

PY - 2023/7/1

Y1 - 2023/7/1

N2 - The optimal approach for prevention of cardiovascular events and reduction of bleeding in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) is still controversial. The aim of our study is to asses our single-center experience with concomitant left atrial appendage occlusion (LAAO) and percutaneous coronary intervention (PCI). 50 patients with ACS without ST elevation and history of AF were randomized after successful PCI to LAAO or conventional medical therapy. The primary endpoints were safety and length of hospitalization. The follow-up period was 30 days. The mean procedural times were 113 ± 23 min PCI + LAAO implantation and 39 ± 19 min of PCI only (p < 0.001), while mean fluoroscopy times were 18 ± 8 min and 12 ± 8 min (p < 0.001), respectively. No procedure-related complications were observed. There was no difference observed for length of hospitalization between two groups. LAAO in patients with ACS and AF undergoing PCI appears safe. Graphical abstract: [Figure not available: see fulltext.]

AB - The optimal approach for prevention of cardiovascular events and reduction of bleeding in patients with acute coronary syndrome (ACS) and atrial fibrillation (AF) is still controversial. The aim of our study is to asses our single-center experience with concomitant left atrial appendage occlusion (LAAO) and percutaneous coronary intervention (PCI). 50 patients with ACS without ST elevation and history of AF were randomized after successful PCI to LAAO or conventional medical therapy. The primary endpoints were safety and length of hospitalization. The follow-up period was 30 days. The mean procedural times were 113 ± 23 min PCI + LAAO implantation and 39 ± 19 min of PCI only (p < 0.001), while mean fluoroscopy times were 18 ± 8 min and 12 ± 8 min (p < 0.001), respectively. No procedure-related complications were observed. There was no difference observed for length of hospitalization between two groups. LAAO in patients with ACS and AF undergoing PCI appears safe. Graphical abstract: [Figure not available: see fulltext.]

KW - Acute coronary syndrome

KW - Atrial fibrillation

KW - Left atrial appendage occlusion

KW - Percutaneous coronary intervention

UR - https://www.scopus.com/pages/publications/85146827632

U2 - 10.1007/s00380-023-02236-x

DO - 10.1007/s00380-023-02236-x

M3 - Article

C2 - 36695858

SN - 0910-8327

VL - 38

SP - 881

EP - 888

JO - Heart and vessels

JF - Heart and vessels

IS - 7

ER -

Feasibility of concomitant left atrial appendage closure and percutaneous coronary intervention in patients with acute coronary syndrome and atrial fibrillation: a randomized pilot study

Abstract

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Keywords

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