Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)

K. Zwart; M. N. G. J. A. Braat; F. H. van der Baan; A. M. May; J. M. L. Roodhart; D. Al-Toma; J. M. M. B. Otten; M. Los; T. Oostergo; R. J. A. Fijneman; J. M. van Dodewaard-de Jong; C. J. A. Punt; G. Meijer; J. J. W. Lagendijk; M. Koopman; M. Intven; G. M. Bol

doi:10.1016/j.ctro.2024.100874

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)

K. Zwart
, M. N. G. J. A. Braat
, F. H. van der Baan
, A. M. May
, J. M. L. Roodhart
, D. Al-Toma
, J. M. M. B. Otten
, M. Los
, T. Oostergo
, R. J. A. Fijneman
, J. M. van Dodewaard-de Jong
, C. J. A. Punt
, G. Meijer
, J. J. W. Lagendijk
, M. Koopman
, M. Intven
, G. M. Bol^*

^*Corresponding author for this work

Utrecht University
Meander Medical Center
St. Antonius Ziekenhuis
Diakonessenhuis Utrecht
Netherlands Cancer Institute

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.

Original language	English
Article number	100874
Journal	Clinical and Translational Radiation Oncology
Volume	49
DOIs	https://doi.org/10.1016/j.ctro.2024.100874
Publication status	Published - 1 Nov 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Oligometastases
SBRT
Single fraction
Systemic therapy
phase I

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10.1016/j.ctro.2024.100874

Feasibility-and-safety-of-single-fraction-sub-ablative-radiotherapy-with-systemic-therapy-in-colorectal-cancer-patients-.pdfFinal published version, 907 KBLicence: CC BY

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Zwart, K., Braat, M. N. G. J. A., van der Baan, F. H., May, A. M., Roodhart, J. M. L., Al-Toma, D., Otten, J. M. M. B., Los, M., Oostergo, T., Fijneman, R. J. A., van Dodewaard-de Jong, J. M., Punt, C. J. A., Meijer, G., Lagendijk, J. J. W., Koopman, M., Intven, M., & Bol, G. M. (2024). Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708). Clinical and Translational Radiation Oncology, 49, Article 100874. https://doi.org/10.1016/j.ctro.2024.100874

@article{4b93cb44819b45e49e3b7dcf26d22d47,

title = "Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)",

abstract = "Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.",

keywords = "Oligometastases, SBRT, Single fraction, Systemic therapy, phase I",

author = "K. Zwart and Braat, \{M. N. G. J. A.\} and \{van der Baan\}, \{F. H.\} and May, \{A. M.\} and Roodhart, \{J. M. L.\} and D. Al-Toma and Otten, \{J. M. M. B.\} and M. Los and T. Oostergo and Fijneman, \{R. J. A.\} and \{van Dodewaard-de Jong\}, \{J. M.\} and Punt, \{C. J. A.\} and G. Meijer and Lagendijk, \{J. J. W.\} and M. Koopman and M. Intven and Bol, \{G. M.\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = nov,

day = "1",

doi = "10.1016/j.ctro.2024.100874",

language = "English",

volume = "49",

journal = "Clinical and Translational Radiation Oncology",

issn = "2405-6308",

publisher = "Elsevier Ireland Ltd",

}

Zwart, K, Braat, MNGJA, van der Baan, FH, May, AM, Roodhart, JML, Al-Toma, D, Otten, JMMB, Los, M, Oostergo, T, Fijneman, RJA, van Dodewaard-de Jong, JM, Punt, CJA, Meijer, G, Lagendijk, JJW, Koopman, M, Intven, M & Bol, GM 2024, 'Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)', Clinical and Translational Radiation Oncology, vol. 49, 100874. https://doi.org/10.1016/j.ctro.2024.100874

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708). / Zwart, K.; Braat, M. N. G. J. A.; van der Baan, F. H. et al.
In: Clinical and Translational Radiation Oncology, Vol. 49, 100874, 01.11.2024.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases

T2 - A multicenter pilot study (NCT05375708)

AU - Zwart, K.

AU - Braat, M. N. G. J. A.

AU - van der Baan, F. H.

AU - May, A. M.

AU - Roodhart, J. M. L.

AU - Al-Toma, D.

AU - Otten, J. M. M. B.

AU - Los, M.

AU - Oostergo, T.

AU - Fijneman, R. J. A.

AU - van Dodewaard-de Jong, J. M.

AU - Punt, C. J. A.

AU - Meijer, G.

AU - Lagendijk, J. J. W.

AU - Koopman, M.

AU - Intven, M.

AU - Bol, G. M.

PY - 2024/11/1

Y1 - 2024/11/1

N2 - Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.

AB - Colorectal cancer patients with ≤10 unresectable metastases were treated with single-fraction sub-ablative radiotherapy in addition to standard of care systemic therapy in a single-arm, open-label, multicenter, pilot study (SIRIUS) to assess feasibility and safety. Results indicate that radiotherapy combined with systemic therapy is feasible and safe in this population.

KW - Oligometastases

KW - SBRT

KW - Single fraction

KW - Systemic therapy

KW - phase I

UR - https://www.scopus.com/pages/publications/85205986375

U2 - 10.1016/j.ctro.2024.100874

DO - 10.1016/j.ctro.2024.100874

M3 - Article

C2 - 39885896

SN - 2405-6308

VL - 49

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

M1 - 100874

ER -

Feasibility and safety of single-fraction sub-ablative radiotherapy with systemic therapy in colorectal cancer patients with ≤ 10 metastases: A multicenter pilot study (NCT05375708)

Abstract

UN SDGs

Keywords

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