Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients

Medicopsis romeroi, a rare brown-pigmented mold, is one of the causes of phaeohyphomycosis, a (sub)cutaneous or soft tissue fungal infection with formation of nodules, cysts or abscesses. Mainly immunocompromised patients are affected, who may experience a wider spectrum of disease with involvement of other tissues, such as the bones or the sinuses. No specific treatment recommendations are available, but surgical excision appears to be the mainstay of treatment, combined with (long-term) antifungal therapy. In this case series, we describe two immunocompromised patients with extensive and persistent skin lesions caused by M. romeroi, and clinical practice recommendations for optimal treatment.