Experimentally-induced autonomic neuropathy: Beneficial effect of a topical acth4–9 analogue on oculomotor nerve regeneration

W P Vandertop; W B de Vries; N C Notermans; C A Tulleken; W H Gispen

doi:10.1227/00006123-199409000-00014

Experimentally-induced autonomic neuropathy: Beneficial effect of a topical acth_4–9 analogue on oculomotor nerve regeneration

W P Vandertop
, W B de Vries
, N C Notermans
, C A Tulleken
, W H Gispen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

MELANOCORTINS, PEPTIDES RELATED to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH_4–9 analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH_4–9 analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery.

Original language	English
Pages (from-to)	457-462
Number of pages	6
Journal	Neurosurgery
Volume	35
Issue number	3
DOIs	https://doi.org/10.1227/00006123-199409000-00014
Publication status	Published - Sept 1994

Keywords

Administration, Topical
Adrenocorticotropic Hormone/pharmacology
Animals
Autonomic Nervous System Diseases/physiopathology
Dose-Response Relationship, Drug
Fibrin Tissue Adhesive
Male
Nerve Regeneration/drug effects
Oculomotor Nerve/drug effects
Peptide Fragments/pharmacology
Pharmaceutical Vehicles
Rats
Rats, Wistar
Reflex, Pupillary/drug effects

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10.1227/00006123-199409000-00014

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title = "Experimentally-induced autonomic neuropathy: Beneficial effect of a topical acth4–9 analogue on oculomotor nerve regeneration",

abstract = "MELANOCORTINS, PEPTIDES RELATED to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH4–9 analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH4–9 analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery.",

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author = "Vandertop, \{W P\} and \{de Vries\}, \{W B\} and Notermans, \{N C\} and Tulleken, \{C A\} and Gispen, \{W H\}",

year = "1994",

month = sep,

doi = "10.1227/00006123-199409000-00014",

language = "English",

volume = "35",

pages = "457--462",

journal = "Neurosurgery",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Experimentally-induced autonomic neuropathy

T2 - Beneficial effect of a topical acth4–9 analogue on oculomotor nerve regeneration

AU - Vandertop, W P

AU - de Vries, W B

AU - Notermans, N C

AU - Tulleken, C A

AU - Gispen, W H

PY - 1994/9

Y1 - 1994/9

N2 - MELANOCORTINS, PEPTIDES RELATED to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH4–9 analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH4–9 analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery.

AB - MELANOCORTINS, PEPTIDES RELATED to corticotropin (ACTH) and melanocyte-stimulating hormone, are known to exert beneficial neurotrophic effects in peripheral sensorimotor neuropathies. This has been demonstrated after both systemic and local administration of the peptides. By photographing the rat's pupil under standardized conditions, the authors have previously shown that systemic administration of a synthetic ACTH4–9 analogue can also be beneficial in autonomic neuropathies. The present study demonstrates that topical application of a synthetic ACTH4–9 analogue incorporated in a two-component fibrin glue enhances the speed of recovery of the parasympathetic nerve fibers in the oculomotor nerve after a crush lesion. This may have implications for future use in neurosurgery.

KW - Administration, Topical

KW - Adrenocorticotropic Hormone/pharmacology

KW - Animals

KW - Autonomic Nervous System Diseases/physiopathology

KW - Dose-Response Relationship, Drug

KW - Fibrin Tissue Adhesive

KW - Male

KW - Nerve Regeneration/drug effects

KW - Oculomotor Nerve/drug effects

KW - Peptide Fragments/pharmacology

KW - Pharmaceutical Vehicles

KW - Rats

KW - Rats, Wistar

KW - Reflex, Pupillary/drug effects

UR - https://www.scopus.com/pages/publications/0028049029

U2 - 10.1227/00006123-199409000-00014

DO - 10.1227/00006123-199409000-00014

M3 - Article

C2 - 7800137

AN - SCOPUS:0028049029

SN - 0148-396X

VL - 35

SP - 457

EP - 462

JO - Neurosurgery

JF - Neurosurgery

IS - 3

ER -

Experimentally-induced autonomic neuropathy: Beneficial effect of a topical acth_4–9 analogue on oculomotor nerve regeneration

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Keywords

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