TY - CHAP
T1 - Evidence-Based Laboratory Medicine
AU - Bossuyt, Patrick M. M.
AU - Glasziou, Paul
AU - Horvath, Andrea R.
PY - 2022/6/6
Y1 - 2022/6/6
N2 - Background Evidence-based laboratory medicine (EBLM) is an approach to medical practice that integrates the best available research evidence about laboratory investigations with the clinical expertise of clinicians, to improve the health and health care outcomes of individual patients. Practicing EBLM enables laboratory professionals to translate test results to clinically relevant information that helps clinicians in delivering effective and cost-effective patient care. Content This chapter provides an overview on how evidence about laboratory tests is generated, how it is synthesized, and how it can be applied to questions about diagnosis, screening, prognosis, or monitoring. The topics covered here introduce the reader to the methodological and practical aspects of EBLM. They include (1) the process and methods of practicing EBLM, (2) the key components and types of evidence used in the evaluation of biomarkers, (3) tools for the assessment of the validity and applicability of the evidence, (4) key aspects of synthesizing the evidence in systematic reviews and meta-analyses, (5) basic principles of how EBLM is applied to other purposes of testing than diagnosis, (6) the challenges and tools of implementing the evidence for achieving best laboratory practice, and (7) the history and future challenges of EBLM.
AB - Background Evidence-based laboratory medicine (EBLM) is an approach to medical practice that integrates the best available research evidence about laboratory investigations with the clinical expertise of clinicians, to improve the health and health care outcomes of individual patients. Practicing EBLM enables laboratory professionals to translate test results to clinically relevant information that helps clinicians in delivering effective and cost-effective patient care. Content This chapter provides an overview on how evidence about laboratory tests is generated, how it is synthesized, and how it can be applied to questions about diagnosis, screening, prognosis, or monitoring. The topics covered here introduce the reader to the methodological and practical aspects of EBLM. They include (1) the process and methods of practicing EBLM, (2) the key components and types of evidence used in the evaluation of biomarkers, (3) tools for the assessment of the validity and applicability of the evidence, (4) key aspects of synthesizing the evidence in systematic reviews and meta-analyses, (5) basic principles of how EBLM is applied to other purposes of testing than diagnosis, (6) the challenges and tools of implementing the evidence for achieving best laboratory practice, and (7) the history and future challenges of EBLM.
UR - https://www.scopus.com/pages/publications/105022007157
U2 - 10.1016/B978-0-323-77572-4.00019-0
DO - 10.1016/B978-0-323-77572-4.00019-0
M3 - Chapter
SN - 0323834701
T3 - Tietz Textbook of Laboratory Medicine: Seventh Edition
SP - 194-194.e21
BT - Tietz Textbook of Laboratory Medicine: Seventh Edition
PB - Elsevier Inc.
ER -