Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer

Kari Tanderup; Nicole Nesvacil; Kathrin Kirchheiner; Monica Serban; Sofia Spampinato; Nina Boje Kibsgaard Jensen; Maximilian Schmid; Stephanie Smet; Henrike Westerveld; Stefan Ecker; Umesh Mahantshetty; Jamema Swamidas; Supriya Chopra; Remi Nout; Li Tee Tan; Lars Fokdal; Alina Sturdza; Ina Jürgenliemk-Schulz; Astrid de Leeuw; Jacob Christian Lindegaard; Christian Kirisits; Richard Pötter

doi:10.1016/j.semradonc.2020.05.008

Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer

Kari Tanderup^*
, Nicole Nesvacil
, Kathrin Kirchheiner
, Monica Serban
, Sofia Spampinato
, Nina Boje Kibsgaard Jensen
, Maximilian Schmid
, Stephanie Smet
, Henrike Westerveld
, Stefan Ecker
, Umesh Mahantshetty
, Jamema Swamidas
, Supriya Chopra
, Remi Nout
, Li Tee Tan
, Lars Fokdal
, Alina Sturdza
, Ina Jürgenliemk-Schulz
, Astrid de Leeuw
, Jacob Christian Lindegaard

Christian Kirisits, Richard Pötter

^*Corresponding author for this work

Aarhus University
Medical University of Vienna
McGill University
KU Leuven
Tata Memorial Hospital
Homi Bhabha National Institute
Leiden University
Cambridge University Hospitals NHS Foundation Trust
University Medical Center Utrecht

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk.

Original language	English
Pages (from-to)	311-327
Number of pages	17
Journal	Seminars in radiation oncology
Volume	30
Issue number	4
Early online date	2020
DOIs	https://doi.org/10.1016/j.semradonc.2020.05.008
Publication status	Published - Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.semradonc.2020.05.008

Cite this

Tanderup, K., Nesvacil, N., Kirchheiner, K., Serban, M., Spampinato, S., Jensen, N. B. K., Schmid, M., Smet, S., Westerveld, H., Ecker, S., Mahantshetty, U., Swamidas, J., Chopra, S., Nout, R., Tan, L. T., Fokdal, L., Sturdza, A., Jürgenliemk-Schulz, I., de Leeuw, A., ... Pötter, R. (2020). Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer. Seminars in radiation oncology, 30(4), 311-327. https://doi.org/10.1016/j.semradonc.2020.05.008

@article{f781d48b0df94cd6968867cd157dc3ee,

title = "Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer",

abstract = "The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk.",

author = "Kari Tanderup and Nicole Nesvacil and Kathrin Kirchheiner and Monica Serban and Sofia Spampinato and Jensen, \{Nina Boje Kibsgaard\} and Maximilian Schmid and Stephanie Smet and Henrike Westerveld and Stefan Ecker and Umesh Mahantshetty and Jamema Swamidas and Supriya Chopra and Remi Nout and Tan, \{Li Tee\} and Lars Fokdal and Alina Sturdza and Ina J{\"u}rgenliemk-Schulz and \{de Leeuw\}, Astrid and Lindegaard, \{Jacob Christian\} and Christian Kirisits and Richard P{\"o}tter",

year = "2020",

month = oct,

doi = "10.1016/j.semradonc.2020.05.008",

language = "English",

volume = "30",

pages = "311--327",

journal = "Seminars in radiation oncology",

issn = "1053-4296",

publisher = "W.B. Saunders Ltd",

number = "4",

}

Tanderup, K, Nesvacil, N, Kirchheiner, K, Serban, M, Spampinato, S, Jensen, NBK, Schmid, M, Smet, S, Westerveld, H, Ecker, S, Mahantshetty, U, Swamidas, J, Chopra, S, Nout, R, Tan, LT, Fokdal, L, Sturdza, A, Jürgenliemk-Schulz, I, de Leeuw, A, Lindegaard, JC, Kirisits, C & Pötter, R 2020, 'Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer', Seminars in radiation oncology, vol. 30, no. 4, pp. 311-327. https://doi.org/10.1016/j.semradonc.2020.05.008

Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer. / Tanderup, Kari; Nesvacil, Nicole; Kirchheiner, Kathrin et al.
In: Seminars in radiation oncology, Vol. 30, No. 4, 10.2020, p. 311-327.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer

AU - Tanderup, Kari

AU - Nesvacil, Nicole

AU - Kirchheiner, Kathrin

AU - Serban, Monica

AU - Spampinato, Sofia

AU - Jensen, Nina Boje Kibsgaard

AU - Schmid, Maximilian

AU - Smet, Stephanie

AU - Westerveld, Henrike

AU - Ecker, Stefan

AU - Mahantshetty, Umesh

AU - Swamidas, Jamema

AU - Chopra, Supriya

AU - Nout, Remi

AU - Tan, Li Tee

AU - Fokdal, Lars

AU - Sturdza, Alina

AU - Jürgenliemk-Schulz, Ina

AU - de Leeuw, Astrid

AU - Lindegaard, Jacob Christian

AU - Kirisits, Christian

AU - Pötter, Richard

PY - 2020/10

Y1 - 2020/10

N2 - The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk.

AB - The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk.

UR - https://www.scopus.com/pages/publications/85087790876

U2 - 10.1016/j.semradonc.2020.05.008

DO - 10.1016/j.semradonc.2020.05.008

M3 - Review article

C2 - 32828387

SN - 1053-4296

VL - 30

SP - 311

EP - 327

JO - Seminars in radiation oncology

JF - Seminars in radiation oncology

IS - 4

ER -

Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this