Epigenetic mechanisms and drug discovery in rheumatology

David F. Tough; Rab K. Prinjha; Paul P. Tak

doi:10.7861/clinmedicine.15-6-s64

Epigenetic mechanisms and drug discovery in rheumatology

David F. Tough
, Rab K. Prinjha
, Paul P. Tak

Affiliatie UvA

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There is a growing understanding of the epigenetic mechanisms that regulate gene expression in healthy conditions and a realisation that dysregulation of these mechanisms is an underlying factor in many human diseases. We discuss studies demonstrating that small molecule inhibitors of epigenetic regulatory proteins can block pathogenic mechanisms associated with rheumatoid arthritis, focusing on the effects of these inhibitors on synovial fibroblasts-fibroblast-like synoviocytes

Original language	English
Pages (from-to)	s64-s71
Journal	Clinical medicine (London, England)
Volume	15
Issue number	Suppl. 6
DOIs	https://doi.org/10.7861/clinmedicine.15-6-s64
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.7861/clinmedicine.15-6-s64

Cite this

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title = "Epigenetic mechanisms and drug discovery in rheumatology",

abstract = "There is a growing understanding of the epigenetic mechanisms that regulate gene expression in healthy conditions and a realisation that dysregulation of these mechanisms is an underlying factor in many human diseases. We discuss studies demonstrating that small molecule inhibitors of epigenetic regulatory proteins can block pathogenic mechanisms associated with rheumatoid arthritis, focusing on the effects of these inhibitors on synovial fibroblasts-fibroblast-like synoviocytes",

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AB - There is a growing understanding of the epigenetic mechanisms that regulate gene expression in healthy conditions and a realisation that dysregulation of these mechanisms is an underlying factor in many human diseases. We discuss studies demonstrating that small molecule inhibitors of epigenetic regulatory proteins can block pathogenic mechanisms associated with rheumatoid arthritis, focusing on the effects of these inhibitors on synovial fibroblasts-fibroblast-like synoviocytes

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DO - 10.7861/clinmedicine.15-6-s64

M3 - Article

C2 - 26634685

SN - 1470-2118

VL - 15

SP - s64-s71

JO - Clinical medicine (London, England)

JF - Clinical medicine (London, England)

IS - Suppl. 6

ER -

Epigenetic mechanisms and drug discovery in rheumatology

Abstract

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