Epac and the cardiovascular system

Martina Schmidt; Carsten Sand; Karl H. Jakobs; Martin C. Michel; Paschal A. Oude Weernink

doi:10.1016/j.coph.2006.10.004

Epac and the cardiovascular system

Martina Schmidt
, Carsten Sand
, Karl H. Jakobs
, Martin C. Michel
, Paschal A. Oude Weernink

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Exchange protein activated by cyclic AMP (Epac) -- a cyclic AMP-activated guanine nucleotide exchange factor for Ras-like GTPases -- has emerged as a novel mediator of pivotal processes in the cardiovascular system, including cellular calcium handling, hypertrophy, integrin-mediated cell adhesion, establishment of cell polarity, cell migration and endothelial barrier functioning. Epac controls these various cellular responses apparently by signaling to several effector proteins. Spatiotemporal dynamics in the subcellular distribution of Epac-driven signaling networks probably determine the net outcome of cyclic AMP signaling in the cardiovascular system

Original language	English
Pages (from-to)	193-200
Journal	Current opinion in pharmacology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.coph.2006.10.004
Publication status	Published - 2007

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10.1016/j.coph.2006.10.004

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title = "Epac and the cardiovascular system",

abstract = "Exchange protein activated by cyclic AMP (Epac) -- a cyclic AMP-activated guanine nucleotide exchange factor for Ras-like GTPases -- has emerged as a novel mediator of pivotal processes in the cardiovascular system, including cellular calcium handling, hypertrophy, integrin-mediated cell adhesion, establishment of cell polarity, cell migration and endothelial barrier functioning. Epac controls these various cellular responses apparently by signaling to several effector proteins. Spatiotemporal dynamics in the subcellular distribution of Epac-driven signaling networks probably determine the net outcome of cyclic AMP signaling in the cardiovascular system",

author = "Martina Schmidt and Carsten Sand and Jakobs, \{Karl H.\} and Michel, \{Martin C.\} and Weernink, \{Paschal A. Oude\}",

year = "2007",

doi = "10.1016/j.coph.2006.10.004",

language = "English",

volume = "7",

pages = "193--200",

journal = "Current opinion in pharmacology",

issn = "1471-4892",

publisher = "Elsevier BV",

number = "2",

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T1 - Epac and the cardiovascular system

AU - Schmidt, Martina

AU - Sand, Carsten

AU - Jakobs, Karl H.

AU - Michel, Martin C.

AU - Weernink, Paschal A. Oude

PY - 2007

Y1 - 2007

N2 - Exchange protein activated by cyclic AMP (Epac) -- a cyclic AMP-activated guanine nucleotide exchange factor for Ras-like GTPases -- has emerged as a novel mediator of pivotal processes in the cardiovascular system, including cellular calcium handling, hypertrophy, integrin-mediated cell adhesion, establishment of cell polarity, cell migration and endothelial barrier functioning. Epac controls these various cellular responses apparently by signaling to several effector proteins. Spatiotemporal dynamics in the subcellular distribution of Epac-driven signaling networks probably determine the net outcome of cyclic AMP signaling in the cardiovascular system

AB - Exchange protein activated by cyclic AMP (Epac) -- a cyclic AMP-activated guanine nucleotide exchange factor for Ras-like GTPases -- has emerged as a novel mediator of pivotal processes in the cardiovascular system, including cellular calcium handling, hypertrophy, integrin-mediated cell adhesion, establishment of cell polarity, cell migration and endothelial barrier functioning. Epac controls these various cellular responses apparently by signaling to several effector proteins. Spatiotemporal dynamics in the subcellular distribution of Epac-driven signaling networks probably determine the net outcome of cyclic AMP signaling in the cardiovascular system

U2 - 10.1016/j.coph.2006.10.004

DO - 10.1016/j.coph.2006.10.004

M3 - Review article

C2 - 17276729

SN - 1471-4892

VL - 7

SP - 193

EP - 200

JO - Current opinion in pharmacology

JF - Current opinion in pharmacology

IS - 2

ER -

Epac and the cardiovascular system

Abstract

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