@article{aa14fa93c23d4954b2a9c71f01747db7,
title = "Endothelial Progenitor Cells and Vascular Alterations in Alzheimer{\textquoteright}s Disease",
abstract = "Alzheimer{\textquoteright}s disease (AD) is a neurodegenerative disease representing the most common type of dementia worldwide. The early diagnosis of AD is very difficult to achieve due to its complexity and the practically unknown etiology. Therefore, this is one of the greatest challenges in the field in order to develop an accurate therapy. Within the different etiological hypotheses proposed for AD, we will focus on the two-hit vascular hypothesis and vascular alterations occurring in the disease. According to this hypothesis, the accumulation of β-amyloid protein in the brain starts as a consequence of damage in the cerebral vasculature. Given that there are several vascular and angiogenic alterations in AD, and that endothelial progenitor cells (EPCs) play a key role in endothelial repair processes, the study of EPCs in AD may be relevant to the disease etiology and perhaps a biomarker and/or therapeutic target. This review focuses on the involvement of endothelial dysfunction in the onset and progression of AD with special emphasis on EPCs as a biomarker and potential therapeutic target.",
keywords = "Alzheimer{\textquoteright}s disease, biomarkers, blood brain barrier dysfunction, endothelial progenitor cells, endothelial repair, neurotoxicity, two-hit vascular hypothesis, vascular alteration",
author = "Ant{\'i}a Custodia and Alberto Ouro and Daniel Romaus-Sanjurjo and P{\'i}as-Peleteiro, \{Juan Manuel\} and \{de Vries\}, \{Helga E.\} and Jos{\'e} Castillo and Tom{\'a}s Sobrino",
note = "Funding Information: This study was partially supported by grants from the Xunta de Galicia (TS: IN607A2018/3, TS: IN607D 2020/09, AC: IN606A-2021/015, and DR-S: IN606B-2021/010), and Science Ministry of Spain (TS: RTI2018-102165-B-I00 and TS: RTC2019-007373-1). Furthermore, this study was also supported by grants from the INTERREG Atlantic Area (TS: EAPA\_791/2018\_ NEUROATLANTIC project), INTER-REG V A Espa{\~n}a Portugal (POCTEP) (TS: 0624\_2IQBIONEURO\_6\_E), and the European Regional Development Fund (ERDF). Moreover, this work was financed by grants from Horizon 2020 \#686009-PANA Project (TS and HV). Finally, TS (CPII17/00027) was recipient of a research contract from the Miguel Servet Program from the Instituto de Salud Carlos III. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: This study was partially supported by grants from the Xunta de Galicia (TS: IN607A2018/3, TS: IN607D 2020/09, AC: IN606A-2021/015, and DR-S: IN606B-2021/010), and Science Ministry of Spain (TS: RTI2018-102165-B-I00 and TS: RTC2019-007373-1). Furthermore, this study was also supported by grants from the INTERREG Atlantic Area (TS: EAPA\_791/2018\_ NEUROATLANTIC project), INTER-REG V A Espa?a Portugal (POCTEP) (TS: 0624\_2IQBIONEURO\_6\_E), and the European Regional Development Fund (ERDF). Moreover, this work was financed by grants from Horizon 2020 \#686009-PANA Project (TS and HV). Finally, TS (CPII17/00027) was recipient of a research contract from the Miguel Servet Program from the Instituto de Salud Carlos III. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: Copyright {\textcopyright} 2022 Custodia, Ouro, Romaus-Sanjurjo, P{\'i}as-Peleteiro, de Vries, Castillo and Sobrino.",
year = "2022",
month = jan,
day = "26",
doi = "10.3389/fnagi.2021.811210",
language = "English",
volume = "13",
journal = "Frontiers in aging neuroscience",
issn = "1663-4365",
publisher = "Frontiers Media SA",
}
SDG 3 Good Health and Well-being