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Endogenous IL-10 protects mice from death during septic peritonitis
T. van der Poll
, A. Marchant
, W. A. Buurman
, L. Berman
, C. V. Keogh
, D. D. Lazarus
, L. Nguyen
, M. Goldman
, L. L. Moldawer
, S. F. Lowry
Other Departments
Affiliatie UvA
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Keyphrases
Interleukin-10
100%
Septic Peritonitis
100%
Cecal Puncture
75%
Cecal Ligation
75%
IL-10 mRNA
37%
Liver
12%
Interleukin-1β
12%
Peak Concentration
12%
Lethality
12%
Spleen
12%
Lung
12%
Interferon-γ
12%
Increased Mortality
12%
Log-rank Test
12%
Protective Mechanism
12%
Endotoxic Shock
12%
IL-10 Production
12%
Rapid Induction
12%
Sustained Production
12%
Anti-TNF mAb
12%
Agricultural and Biological Sciences
Mouse
100%
Interleukin 10
100%
Messenger RNA
25%
Blood Plasma
25%
Tumor Necrosis Factor
25%
Lung
8%
Pretreatment
8%
Interleukin-1
8%
Pharmacology, Toxicology and Pharmaceutical Science
Peritonitis
100%
Interleukin 10
100%
Tumor Necrosis Factor
25%
Messenger RNA
25%
Lethality
8%
Septic Shock
8%
Immunology and Microbiology
Interleukin 10
100%
Peritonitis
100%
Tumor Necrosis Factor
25%
Blood Plasma
25%
Interleukin-1
8%