Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization

Ilse Houtenbos; Theresia M. Westers; Gert J. Ossenkoppele; Arjan A. van de Loosdrecht

doi:10.1016/j.imbio.2005.05.019

Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization

Ilse Houtenbos
, Theresia M. Westers
, Gert J. Ossenkoppele
, Arjan A. van de Loosdrecht^*

^*Corresponding author for this work

VU Medical Center

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.

Original language	English
Pages (from-to)	249-257
Number of pages	9
Journal	Immunobiology
Volume	210
Issue number	2-4
DOIs	https://doi.org/10.1016/j.imbio.2005.05.019
Publication status	Published - 19 Aug 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acute myeloid leukaemia
Dendritic cells
Immunological synapse
Immunotherapy

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10.1016/j.imbio.2005.05.019

Cite this

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title = "Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization",

abstract = "Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to na{\"i}ve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.",

keywords = "Acute myeloid leukaemia, Dendritic cells, Immunological synapse, Immunotherapy",

author = "Ilse Houtenbos and Westers, \{Theresia M.\} and Ossenkoppele, \{Gert J.\} and \{van de Loosdrecht\}, \{Arjan A.\}",

year = "2005",

month = aug,

day = "19",

doi = "10.1016/j.imbio.2005.05.019",

language = "English",

volume = "210",

pages = "249--257",

journal = "Immunobiology",

issn = "0171-2985",

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number = "2-4",

}

TY - JOUR

T1 - Employing the immunological synapse in AML

T2 - Development of leukemic dendritic cells for active specific immunization

AU - Houtenbos, Ilse

AU - Westers, Theresia M.

AU - Ossenkoppele, Gert J.

AU - van de Loosdrecht, Arjan A.

PY - 2005/8/19

Y1 - 2005/8/19

N2 - Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.

AB - Cytotoxic T cells directed against leukemic blasts have been observed in patients with acute myeloid leukemia (AML). However, generation of efficient T-cell responses is hampered due to several factors that enable AML blasts to protect themselves from the patients immune system. Improved immune responses can be established by the differentiation of AML blasts into AML-derived dendritic cells (DC) thereby conserving their intrinsic leukemia specific antigens and obtaining full capacity to present these antigens to naïve T cells. This review discusses increased immunogenicity of AML blasts by differentiation into AML-DC and describes ways to augment the AML-DC vaccination approach.

KW - Acute myeloid leukaemia

KW - Dendritic cells

KW - Immunological synapse

KW - Immunotherapy

UR - https://www.scopus.com/pages/publications/22644439034

U2 - 10.1016/j.imbio.2005.05.019

DO - 10.1016/j.imbio.2005.05.019

M3 - Review article

C2 - 16164032

SN - 0171-2985

VL - 210

SP - 249

EP - 257

JO - Immunobiology

JF - Immunobiology

IS - 2-4

ER -

Employing the immunological synapse in AML: Development of leukemic dendritic cells for active specific immunization

Abstract

UN SDGs

Keywords

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