TY - CHAP
T1 - Emerging concepts in treating cartilage, osteochondral defects, and osteoarthritis of the knee and ankle
AU - Pereira, H. lder
AU - Cengiz, Ibrahim Fatih
AU - Vilela, Carlos
AU - Ripoll, Pedro L.
AU - Espregueira-Mendes, João
AU - Oliveira, J. Miguel
AU - Reis, Rui L.
AU - Niek van Dijk, C.
PY - 2018
Y1 - 2018
N2 - The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches. This work addresses the state of the art concerning basic science comparing the knee and ankle as well as current options for treatment. Furthermore, the most promising research developments promising new options for the future are discussed.
AB - The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches. This work addresses the state of the art concerning basic science comparing the knee and ankle as well as current options for treatment. Furthermore, the most promising research developments promising new options for the future are discussed.
UR - https://www.scopus.com/pages/publications/85046720709
UR - https://www.ncbi.nlm.nih.gov/pubmed/29736568
U2 - 10.1007/978-3-319-76735-2_2
DO - 10.1007/978-3-319-76735-2_2
M3 - Chapter
C2 - 29736568
VL - 1059
T3 - Advances in Experimental Medicine and Biology
SP - 25
EP - 62
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -