Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure

Dirk J. van Veldhuisen; Armand R.J. Girbes; Stan A.J. van den Broek; Pieter A. de Graeff; Wiek H. van Gilst; K. I. Lie

doi:10.1016/0002-9149(93)90920-8

Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure

Dirk J. van Veldhuisen^*
, Armand R.J. Girbes
, Stan A.J. van den Broek
, Pieter A. de Graeff
, Wiek H. van Gilst
, K. I. Lie

^*Corresponding author for this work

University of Groningen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Congestive heart failure (CHF) is accompanied by increased levels of plasma norepinephrine (PNE) at rest. During exercise, PNE levels increase rapidly in patients with CHF,¹ causing skeletal vasoconstriction and muscle underperfusion. Because long-term sympathetic activation may be detrimental in patients with CHF,² inhibition of this sympathetic drive would appear to be beneficial. The oral dopamine agonist ibopamine causes vasodilation and reduces PNE levels at rest in patients with CHF.³ However, the influence of ibopamine on peak oxygen consumption (VO₂) and PNE levels during exercise in patients with CHF is unknown, and was investigated in this study.

Original language	English
Pages (from-to)	992-994
Number of pages	3
Journal	The American Journal of Cardiology
Volume	71
Issue number	11
DOIs	https://doi.org/10.1016/0002-9149(93)90920-8
Publication status	Published - 15 Apr 1993

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title = "Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure",

abstract = "Congestive heart failure (CHF) is accompanied by increased levels of plasma norepinephrine (PNE) at rest. During exercise, PNE levels increase rapidly in patients with CHF,1 causing skeletal vasoconstriction and muscle underperfusion. Because long-term sympathetic activation may be detrimental in patients with CHF,2 inhibition of this sympathetic drive would appear to be beneficial. The oral dopamine agonist ibopamine causes vasodilation and reduces PNE levels at rest in patients with CHF.3 However, the influence of ibopamine on peak oxygen consumption (VO2) and PNE levels during exercise in patients with CHF is unknown, and was investigated in this study.",

author = "\{van Veldhuisen\}, \{Dirk J.\} and Girbes, \{Armand R.J.\} and \{van den Broek\}, \{Stan A.J.\} and \{de Graeff\}, \{Pieter A.\} and \{van Gilst\}, \{Wiek H.\} and Lie, \{K. I.\}",

year = "1993",

month = apr,

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doi = "10.1016/0002-9149(93)90920-8",

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T1 - Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure

AU - van Veldhuisen, Dirk J.

AU - Girbes, Armand R.J.

AU - van den Broek, Stan A.J.

AU - de Graeff, Pieter A.

AU - van Gilst, Wiek H.

AU - Lie, K. I.

PY - 1993/4/15

Y1 - 1993/4/15

N2 - Congestive heart failure (CHF) is accompanied by increased levels of plasma norepinephrine (PNE) at rest. During exercise, PNE levels increase rapidly in patients with CHF,1 causing skeletal vasoconstriction and muscle underperfusion. Because long-term sympathetic activation may be detrimental in patients with CHF,2 inhibition of this sympathetic drive would appear to be beneficial. The oral dopamine agonist ibopamine causes vasodilation and reduces PNE levels at rest in patients with CHF.3 However, the influence of ibopamine on peak oxygen consumption (VO2) and PNE levels during exercise in patients with CHF is unknown, and was investigated in this study.

AB - Congestive heart failure (CHF) is accompanied by increased levels of plasma norepinephrine (PNE) at rest. During exercise, PNE levels increase rapidly in patients with CHF,1 causing skeletal vasoconstriction and muscle underperfusion. Because long-term sympathetic activation may be detrimental in patients with CHF,2 inhibition of this sympathetic drive would appear to be beneficial. The oral dopamine agonist ibopamine causes vasodilation and reduces PNE levels at rest in patients with CHF.3 However, the influence of ibopamine on peak oxygen consumption (VO2) and PNE levels during exercise in patients with CHF is unknown, and was investigated in this study.

UR - https://www.scopus.com/pages/publications/0027412215

U2 - 10.1016/0002-9149(93)90920-8

DO - 10.1016/0002-9149(93)90920-8

M3 - Article

C2 - 8465795

SN - 0002-9149

VL - 71

SP - 992

EP - 994

JO - The American Journal of Cardiology

JF - The American Journal of Cardiology

IS - 11

ER -

Effects of ibopamine on the increase in plasma norepinephrine levels during exercise in congestive heart failure

Abstract

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