Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes

A. A. Mihas; R. G. Gibson; T. A. Mihas

Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes

A. A. Mihas^*
, R. G. Gibson
, T. A. Mihas

^*Corresponding author for this work

University of Mississippi

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation.

Original language	English
Pages (from-to)	123-126
Journal	Research communications in chemical pathology and pharmacology
Volume	73
Issue number	1
Publication status	Published - 1991
Externally published	Yes

Cite this

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title = "Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes",

abstract = "The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation.",

author = "Mihas, \{A. A.\} and Gibson, \{R. G.\} and Mihas, \{T. A.\}",

year = "1991",

language = "English",

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pages = "123--126",

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AU - Mihas, A. A.

AU - Gibson, R. G.

AU - Mihas, T. A.

PY - 1991

Y1 - 1991

N2 - The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation.

AB - The gastrointestinal peptides secretin and cholecystokinin were found to inhibit the incorporation of 3H-thymidine in the lymphocyte transformation reaction in response to phytohemagglutinin. Both peptides inhibited lymphocyte activation in a dose responsive fashion. This inhibition was not due to the toxicity of these substances, as the lymphocytes remained intact and capable of excluding trypan blue. Neither glucagon nor gastrin had any effects of lymphocyte transformation.

UR - https://www.scopus.com/pages/publications/0026397586

UR - https://www.ncbi.nlm.nih.gov/pubmed/1882123

M3 - Article

C2 - 1882123

SN - 0034-5164

VL - 73

SP - 123

EP - 126

JO - Research communications in chemical pathology and pharmacology

JF - Research communications in chemical pathology and pharmacology

IS - 1

ER -

Effects of gastrointestinal hormonal peptides on the transformation of human peripheral lymphocytes

Abstract

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