Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis

doi:10.1007/s41999-025-01229-5

Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis

Amsterdam UMC
Amsterdam UMC - University of Amsterdam
University of Liverpool
Istanbul University
University of Texas Health Science Center at Houston
Jagiellonian University Medical College
IRCCS Ospedale San Raffaele
Heidelberg University
University of Health Sciences
Liv Hospital Vadistanbul
Istituto Nazionale di Riposo e Cura per Anziani - Ancona
Hellenic Society for the Study and Research of Ageing
Charles University
University of South Bohemia
Utrecht University
Cornell University
Marche Polytechnic University
Saint Camillus International University of Health and Medical Sciences
University of Florence
University of British Columbia

Research output: Contribution to journal › Review article › Academic › peer-review

38 Downloads (Pure)

Abstract

Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.

Original language	English
Article number	ARTN CD008161
Pages (from-to)	1353-1387
Number of pages	35
Journal	European geriatric medicine
Volume	16
Issue number	4
Early online date	2025
DOIs	https://doi.org/10.1007/s41999-025-01229-5
Publication status	Published - Aug 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adverse outcome
Benefit
Diuretics
Efficacy
Meta-analysis
Umbrella review

Access to Document

10.1007/s41999-025-01229-5

Effectiveness-and-safety-of-chronic-diuretic-use-in-older-adults.pdfFinal published version, 1.33 MBLicence: CC BY

Cite this

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis (2025). Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. European geriatric medicine, 16(4), 1353-1387. Article ARTN CD008161. https://doi.org/10.1007/s41999-025-01229-5

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis. / Effectiveness and safety of chronic diuretic use in older adults : an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. In: European geriatric medicine. 2025 ; Vol. 16, No. 4. pp. 1353-1387.

@article{5cdbb65a1bbb464ea1cc703f91f6b39b,

title = "Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials",

abstract = "Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.",

keywords = "Adverse outcome, Benefit, Diuretics, Efficacy, Meta-analysis, Umbrella review",

author = "\{European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis\} and \{van Poelgeest\}, Eveline and Konstantinos Prokopidis and Tuğba Erdogan and Kwak, \{Min Ji\} and Karolina Piotrowicz and Luca Paoletti and Annette Eidam and Ko{\c c}ak, \{Fatma {\"O}zge Kayhan\} and Birkan Ilhan and Alessia Beccacece and George Soulis and Serdar {\"O}zk{\"o}k and Gulistan Bahat and Eva Topinkov{\'a} and Joost Daams and Handoko, \{M. Louis\} and Parag Goyal and Jerzy G{\c a}sowski and Antonio Cherubini and Nicola Veronese and Testa, \{Giuseppe Dario\} and Wade Thompson and \{van der Velde\}, Nathalie",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = aug,

doi = "10.1007/s41999-025-01229-5",

language = "English",

volume = "16",

pages = "1353--1387",

journal = "European geriatric medicine",

issn = "1878-7649",

publisher = "Elsevier-Masson",

number = "4",

}

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis 2025, 'Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials', European geriatric medicine, vol. 16, no. 4, ARTN CD008161, pp. 1353-1387. https://doi.org/10.1007/s41999-025-01229-5

Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. / European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis.
In: European geriatric medicine, Vol. 16, No. 4, ARTN CD008161, 08.2025, p. 1353-1387.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Effectiveness and safety of chronic diuretic use in older adults

T2 - an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

AU - European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis

AU - van Poelgeest, Eveline

AU - Prokopidis, Konstantinos

AU - Erdogan, Tuğba

AU - Kwak, Min Ji

AU - Piotrowicz, Karolina

AU - Paoletti, Luca

AU - Eidam, Annette

AU - Koçak, Fatma Özge Kayhan

AU - Ilhan, Birkan

AU - Beccacece, Alessia

AU - Soulis, George

AU - Özkök, Serdar

AU - Bahat, Gulistan

AU - Topinková, Eva

AU - Daams, Joost

AU - Handoko, M. Louis

AU - Goyal, Parag

AU - Gąsowski, Jerzy

AU - Cherubini, Antonio

AU - Veronese, Nicola

AU - Testa, Giuseppe Dario

AU - Thompson, Wade

AU - van der Velde, Nathalie

PY - 2025/8

Y1 - 2025/8

N2 - Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.

AB - Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.

KW - Adverse outcome

KW - Benefit

KW - Diuretics

KW - Efficacy

KW - Meta-analysis

KW - Umbrella review

UR - https://www.scopus.com/pages/publications/105006576244

U2 - 10.1007/s41999-025-01229-5

DO - 10.1007/s41999-025-01229-5

M3 - Review article

C2 - 40413712

SN - 1878-7649

VL - 16

SP - 1353

EP - 1387

JO - European geriatric medicine

JF - European geriatric medicine

IS - 4

M1 - ARTN CD008161

ER -

European Geriatric Medicine Society Special Interest Groups of i. Pharmacology; ii. Cardiovascular Disease and iii. Systematic Review and Meta-analysis. Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. European geriatric medicine. 2025 Aug;16(4):1353-1387. ARTN CD008161. Epub 2025. doi: 10.1007/s41999-025-01229-5

Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this