Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile- associated disease

S. B. Debast; E. Van Kregten; K. M.G. Oskam; T. Van Den Berg; R. J. Van Den Berg; E. J. Kuijper

doi:10.1111/j.1469-0691.2008.01999.x

Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile- associated disease

S. B. Debast^*
, E. Van Kregten
, K. M.G. Oskam
, T. Van Den Berg
, R. J. Van Den Berg
, E. J. Kuijper

^*Corresponding author for this work

St Jansdal Hospital
Meander Medical Center
National Reference Laboratory for Clostridium Difficile, Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands
Leiden University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The effect on diagnostic yield of testing sequential stools was assessed during two hospital epidemics of Clostridium difficile. Using a rapid immunoassay, C. difficile- associated disease was diagnosed in 237 diarrhoeal patients, of whom 204 (86%) were diagnosed from the first faeces sample and 12 (5%) were diagnosed from follow-up samples obtained within 1week. The remaining 21 (9%) patients yielded a positive test from stools obtained >1 week after the initial negative sample. It was concluded that repeated testing of stools for C. difficile toxin is of value in controlling outbreaks of C. difficile infection.

Original language	English
Pages (from-to)	622-624
Number of pages	3
Journal	Clinical microbiology and infection
Volume	14
Issue number	6
DOIs	https://doi.org/10.1111/j.1469-0691.2008.01999.x
Publication status	Published - Jun 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clostridium difficile
Diagnostic yield
Diarrhoea
Immunoassay
Repeated tests
Toxin detection

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10.1111/j.1469-0691.2008.01999.x

Cite this

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title = "Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile- associated disease",

abstract = "The effect on diagnostic yield of testing sequential stools was assessed during two hospital epidemics of Clostridium difficile. Using a rapid immunoassay, C. difficile- associated disease was diagnosed in 237 diarrhoeal patients, of whom 204 (86\%) were diagnosed from the first faeces sample and 12 (5\%) were diagnosed from follow-up samples obtained within 1week. The remaining 21 (9\%) patients yielded a positive test from stools obtained >1 week after the initial negative sample. It was concluded that repeated testing of stools for C. difficile toxin is of value in controlling outbreaks of C. difficile infection.",

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T1 - Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile- associated disease

AU - Debast, S. B.

AU - Van Kregten, E.

AU - Oskam, K. M.G.

AU - Van Den Berg, T.

AU - Van Den Berg, R. J.

AU - Kuijper, E. J.

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N2 - The effect on diagnostic yield of testing sequential stools was assessed during two hospital epidemics of Clostridium difficile. Using a rapid immunoassay, C. difficile- associated disease was diagnosed in 237 diarrhoeal patients, of whom 204 (86%) were diagnosed from the first faeces sample and 12 (5%) were diagnosed from follow-up samples obtained within 1week. The remaining 21 (9%) patients yielded a positive test from stools obtained >1 week after the initial negative sample. It was concluded that repeated testing of stools for C. difficile toxin is of value in controlling outbreaks of C. difficile infection.

AB - The effect on diagnostic yield of testing sequential stools was assessed during two hospital epidemics of Clostridium difficile. Using a rapid immunoassay, C. difficile- associated disease was diagnosed in 237 diarrhoeal patients, of whom 204 (86%) were diagnosed from the first faeces sample and 12 (5%) were diagnosed from follow-up samples obtained within 1week. The remaining 21 (9%) patients yielded a positive test from stools obtained >1 week after the initial negative sample. It was concluded that repeated testing of stools for C. difficile toxin is of value in controlling outbreaks of C. difficile infection.

KW - Clostridium difficile

KW - Diagnostic yield

KW - Diarrhoea

KW - Immunoassay

KW - Repeated tests

KW - Toxin detection

UR - https://www.scopus.com/pages/publications/43149125188

U2 - 10.1111/j.1469-0691.2008.01999.x

DO - 10.1111/j.1469-0691.2008.01999.x

M3 - Article

C2 - 18393996

SN - 1198-743X

VL - 14

SP - 622

EP - 624

JO - Clinical microbiology and infection

JF - Clinical microbiology and infection

IS - 6

ER -

Effect on diagnostic yield of repeated stool testing during outbreaks of Clostridium difficile- associated disease

Abstract

UN SDGs

Keywords

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