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Early intervention for obsessive compulsive disorder: An expert consensus statement

  • Naomi A. Fineberg
  • , Bernardo Dell'Osso
  • , Umberto Albert
  • , Giuseppe Maina
  • , Daniel Geller
  • , Lior Carmi
  • , Nick Sireau
  • , Susanne Walitza
  • , Giacomo Grassi
  • , Stefano Pallanti
  • , Eric Hollander
  • , Vlasios Brakoulias
  • , Jose M. Menchon
  • , Donatella Marazziti
  • , Konstantinos Ioannidis
  • , Annemieke Apergis-Schoute
  • , Dan J. Stein
  • , Danielle C. Cath
  • , Dick J. Veltman
  • , Michael van Ameringen
  • Leonardo F. Fontenelle, Roseli G. Shavitt, Daniel Costa, Juliana B. Diniz, Joseph Zohar
  • Hertfordshire Partnership University NHS Foundation Trust, AL8 6HG Welwyn Garden City, United Kingdom
  • University of Hertfordshire
  • University of Cambridge
  • Ospedale Luigi Sacco
  • Department of Psychiatry, 20157 Milan, Italy
  • Stanford University
  • International Centre for Rural Health of the San Paolo Hospital
  • Bologna University Hospital
  • University of Turin
  • San Luigi Gonzaga University Hospital, Torino, Italy
  • Brigham and Women’s Hospital
  • Tel Aviv University
  • Orchard, United Kingdom
  • University of Zurich
  • University of Florence
  • Yeshiva University
  • Western Sydney Area Health Service, Sydney, Australia
  • University of Barcelona
  • University of Pisa
  • Cambridge & Peterborough NHS Foundation Trust, Cambridge, United Kingdom
  • University of Leicester
  • University of Cape Town
  • University of Groningen
  • McMaster University
  • Universidade Federal do Rio de Janeiro
  • Monash University
  • Universidade de São Paulo

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. The statement draws together evidence from epidemiological, clinical, health economic and brain imaging studies documenting the negative impact associated with treatment delay on clinical outcomes, and supporting the importance of early clinical intervention. It draws parallels between OCD and other disorders for which early intervention is recognized as beneficial, such as psychotic disorders and impulsive-compulsive disorders associated with problematic usage of the Internet, for which early intervention may prevent the development of later addictive disorders. It also generates new heuristics for exploring the brain-based mechanisms moderating the ‘toxic’ effect of an extended DUI in OCD. The statement concludes that there is a global unmet need for early intervention services for OC related disorders to reduce the unnecessary suffering and costly disability associated with under-treatment. New clinical staging models for OCD that may be used to facilitate primary, secondary and tertiary prevention within this context are proposed.
Original languageEnglish
Pages (from-to)549-565
Number of pages17
JournalEuropean neuropsychopharmacology
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Compulsive
  • Duration of untreated illness
  • Early intervention
  • OCD
  • Obsessive
  • Staging

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