Early Crohn’s disease: can we change the disease course?

Geert D’Haens; Melek Simsek

doi:10.1038/s41575-025-01072-w

Early Crohn’s disease: can we change the disease course?

Geert D’Haens^*
, Melek Simsek

^*Corresponding author for this work

Amsterdam UMC - University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Current treatments for Crohn’s disease prioritize early intervention with biological therapies, with several landmark trials demonstrating that starting biologic agents within the first years of diagnosis leads to superior patient outcomes. Although challenges remain, early use of biological treatments is increasingly supported in managing moderate to severe Crohn’s disease.

Original language	English
Article number	e000123
Pages (from-to)	367-368
Number of pages	2
Journal	Nature Reviews Gastroenterology and Hepatology
Volume	22
Issue number	6
Early online date	2025
DOIs	https://doi.org/10.1038/s41575-025-01072-w
Publication status	Published - Jun 2025

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abstract = "Current treatments for Crohn{\textquoteright}s disease prioritize early intervention with biological therapies, with several landmark trials demonstrating that starting biologic agents within the first years of diagnosis leads to superior patient outcomes. Although challenges remain, early use of biological treatments is increasingly supported in managing moderate to severe Crohn{\textquoteright}s disease.",

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Early Crohn’s disease: can we change the disease course?

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