Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

A. Zer; M. J. Ahn; F. Barlesi; L. Bubendorf; D. de Ruysscher; P. Garrido; O. Gautschi; L. E. Hendriks; P. A. Jänne; K. M. Kerr; C. Mascaux; T. Mitsudomi; S. Peters; C. Rolfo; A. Sacher; S. Senan; P. Ugalde; N. B. Leighl

doi:10.1016/j.annonc.2025.08.003

Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

A. Zer
, M. J. Ahn
, F. Barlesi
, L. Bubendorf
, D. de Ruysscher
, P. Garrido
, O. Gautschi
, L. E. Hendriks
, P. A. Jänne
, K. M. Kerr
, C. Mascaux
, T. Mitsudomi
, S. Peters
, C. Rolfo
, A. Sacher
, S. Senan
, P. Ugalde
, N. B. Leighl

Technion-Israel Institute of Technology
Samsung Medical Center, Sungkyunkwan university
Institut de Cancerologie Gustave Roussy
University of Basel
Maastricht University
Erasmus University Rotterdam
Hospital Ramon y Cajal
Kantonsspital Luzern
University of Bern
Dana-Farber Cancer Institute
NHS Grampian
Les Hôpitaux Universitaires de Strasbourg
Kindai University
University of Lausanne
Ohio State University
Princess Margaret Hospital Cancer Centre
Vrije Universiteit Amsterdam
Harvard University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

•This ESMO Clinical Practice Guideline provides key recommendations for managing early and locally advanced NSCLC. •The guideline covers diagnosis, staging, risk assessment, treatment and follow-up. •Treatment algorithms for resectable and unresectable disease are provided. •The authors encompass a multidisciplinary group of experts from different institutions and countries. •Recommendations are based on available scientific data and the authors’ collective expert opinion.

Original language	English
Journal	Annals of oncology
Early online date	2025
DOIs	https://doi.org/10.1016/j.annonc.2025.08.003
Publication status	E-pub ahead of print - 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

diagnosis
early non-small-cell lung cancer (NSCLC)
guideline
staging
treatment

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10.1016/j.annonc.2025.08.003

Cite this

Zer, A., Ahn, M. J., Barlesi, F., Bubendorf, L., de Ruysscher, D., Garrido, P., Gautschi, O., Hendriks, L. E., Jänne, P. A., Kerr, K. M., Mascaux, C., Mitsudomi, T., Peters, S., Rolfo, C., Sacher, A., Senan, S., Ugalde, P., & Leighl, N. B. (2025). Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of oncology. Advance online publication. https://doi.org/10.1016/j.annonc.2025.08.003

@article{99ee69ded8994b8db1abdf5dc245d27d,

title = "Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up",

abstract = "•This ESMO Clinical Practice Guideline provides key recommendations for managing early and locally advanced NSCLC. •The guideline covers diagnosis, staging, risk assessment, treatment and follow-up. •Treatment algorithms for resectable and unresectable disease are provided. •The authors encompass a multidisciplinary group of experts from different institutions and countries. •Recommendations are based on available scientific data and the authors{\textquoteright} collective expert opinion.",

keywords = "diagnosis, early non-small-cell lung cancer (NSCLC), guideline, staging, treatment",

author = "A. Zer and Ahn, \{M. J.\} and F. Barlesi and L. Bubendorf and \{de Ruysscher\}, D. and P. Garrido and O. Gautschi and Hendriks, \{L. E.\} and J{\"a}nne, \{P. A.\} and Kerr, \{K. M.\} and C. Mascaux and T. Mitsudomi and S. Peters and C. Rolfo and A. Sacher and S. Senan and P. Ugalde and Leighl, \{N. B.\}",

note = "Publisher Copyright: {\textcopyright} 2025 European Society for Medical Oncology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.",

year = "2025",

doi = "10.1016/j.annonc.2025.08.003",

language = "English",

journal = "Annals of oncology",

issn = "0923-7534",

publisher = "Oxford University Press",

}

Zer, A, Ahn, MJ, Barlesi, F, Bubendorf, L, de Ruysscher, D, Garrido, P, Gautschi, O, Hendriks, LE, Jänne, PA, Kerr, KM, Mascaux, C, Mitsudomi, T, Peters, S, Rolfo, C, Sacher, A, Senan, S, Ugalde, P & Leighl, NB 2025, 'Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up', Annals of oncology. https://doi.org/10.1016/j.annonc.2025.08.003

TY - JOUR

T1 - Early and locally advanced non-small-cell lung cancer

T2 - ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

AU - Zer, A.

AU - Ahn, M. J.

AU - Barlesi, F.

AU - Bubendorf, L.

AU - de Ruysscher, D.

AU - Garrido, P.

AU - Gautschi, O.

AU - Hendriks, L. E.

AU - Jänne, P. A.

AU - Kerr, K. M.

AU - Mascaux, C.

AU - Mitsudomi, T.

AU - Peters, S.

AU - Rolfo, C.

AU - Sacher, A.

AU - Senan, S.

AU - Ugalde, P.

AU - Leighl, N. B.

N1 - Publisher Copyright: © 2025 European Society for Medical Oncology. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

PY - 2025

Y1 - 2025

N2 - •This ESMO Clinical Practice Guideline provides key recommendations for managing early and locally advanced NSCLC. •The guideline covers diagnosis, staging, risk assessment, treatment and follow-up. •Treatment algorithms for resectable and unresectable disease are provided. •The authors encompass a multidisciplinary group of experts from different institutions and countries. •Recommendations are based on available scientific data and the authors’ collective expert opinion.

AB - •This ESMO Clinical Practice Guideline provides key recommendations for managing early and locally advanced NSCLC. •The guideline covers diagnosis, staging, risk assessment, treatment and follow-up. •Treatment algorithms for resectable and unresectable disease are provided. •The authors encompass a multidisciplinary group of experts from different institutions and countries. •Recommendations are based on available scientific data and the authors’ collective expert opinion.

KW - diagnosis

KW - early non-small-cell lung cancer (NSCLC)

KW - guideline

KW - staging

KW - treatment

UR - https://www.scopus.com/pages/publications/105018015269

U2 - 10.1016/j.annonc.2025.08.003

DO - 10.1016/j.annonc.2025.08.003

M3 - Article

C2 - 40885528

SN - 0923-7534

JO - Annals of oncology

JF - Annals of oncology

ER -

Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Abstract

UN SDGs

Keywords

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