Dynamic Prediction Models for Recurrent Pregnancy Loss

In the absence of evidence-based therapeutic options for the majority of couples with recurrent pregnancy loss (RPL) it is considered significant to offer supportive care, including reliable counseling regarding the prognosis of subsequent pregnancies. Currently, various prediction models are available, with a focus on couples with unexplained RPL. All of them having drawbacks like substantial risk of bias, lack of performance measures and applicability. A new prediction model, using more predictors, such as male predictors and focusing on cumulative live birth rates over a reasonable time period is currently needed. In addition, this model should have the ability to provide reliable predictions at later time points, a so-called dynamic prediction model.