Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Erik B. van den Akker; Stavros Makrodimitris; Marc Hulsman; Martijn H. Brugman; Tatjana Nikolic; Ted Bradley; Quinten Waisfisz; Frank Baas; Marja E. Jakobs; Daphne de Jong; P. Eline Slagboom; Frank J. T. Staal; Marcel J. T. Reinders; Henne Holstege

doi:10.1038/s41375-020-01086-0

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

Erik B. van den Akker^*
, Stavros Makrodimitris
, Marc Hulsman
, Martijn H. Brugman
, Tatjana Nikolic
, Ted Bradley
, Quinten Waisfisz
, Frank Baas
, Marja E. Jakobs
, Daphne de Jong
, P. Eline Slagboom
, Frank J. T. Staal
, Marcel J. T. Reinders
, Henne Holstege^*

^*Corresponding author for this work

Leiden University Medical Center
Delft University of Technology
Vrije Universiteit Amsterdam
Amsterdam UMC - University of Amsterdam
Vrije Universiteit (VU) Amsterdam and VU Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	2125-2129
Number of pages	5
Journal	Leukemia
Volume	35
Issue number	7
Early online date	2020
DOIs	https://doi.org/10.1038/s41375-020-01086-0
Publication status	Published - Jul 2021

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Dynamic-clonal-hematopoiesis-and-functional-t-cell-immunity-in-a-supercentenarian.pdfFinal published version, 1.47 MBLicence: CC BY

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van den Akker, E. B., Makrodimitris, S., Hulsman, M., Brugman, M. H., Nikolic, T., Bradley, T., Waisfisz, Q., Baas, F., Jakobs, M. E., de Jong, D., Slagboom, P. E., Staal, F. J. T., Reinders, M. J. T., & Holstege, H. (2021). Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian. Leukemia, 35(7), 2125-2129. https://doi.org/10.1038/s41375-020-01086-0

@article{3625ad7d05cb420eae929781d34044b2,

title = "Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian",

author = "\{van den Akker\}, \{Erik B.\} and Stavros Makrodimitris and Marc Hulsman and Brugman, \{Martijn H.\} and Tatjana Nikolic and Ted Bradley and Quinten Waisfisz and Frank Baas and Jakobs, \{Marja E.\} and \{de Jong\}, Daphne and Slagboom, \{P. Eline\} and Staal, \{Frank J. T.\} and Reinders, \{Marcel J. T.\} and Henne Holstege",

note = "Funding Information: Stichting Diorapthe (VSM.14.04.14.02), Stichting VUmc Fonds and the Horstingstuit Foundation. The Leiden Longevity Study has received funding from the European Union{\textquoteright}s Seventh Framework Programme (FP7/2007–2011) under grant agreement number 259679. This study was supported by the Netherlands Consortium for Healthy Ageing (grant 050-060-810), in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO); by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). FJTS is funded in part by ZonMw E-RARE (113.302.002) and EU H2020 project RECOMB (755170). EvdA is funded by a personal grant of the Dutch Research Council (NWO; VENI: 09150161810095). Funding Information: Acknowledgements We thank W111 for her enthusiasm in study participation, for allowing repeated sample collection and agreeing to post mortem brain donation. Our acknowledgements also go out to her family, for their continuous support of this study. The 100-plus Study was supported by Stichting Alzheimer Nederland (WE09.2014-03),",

year = "2021",

month = jul,

doi = "10.1038/s41375-020-01086-0",

language = "English",

volume = "35",

pages = "2125--2129",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "7",

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TY - JOUR

T1 - Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

AU - van den Akker, Erik B.

AU - Makrodimitris, Stavros

AU - Hulsman, Marc

AU - Brugman, Martijn H.

AU - Nikolic, Tatjana

AU - Bradley, Ted

AU - Waisfisz, Quinten

AU - Baas, Frank

AU - Jakobs, Marja E.

AU - de Jong, Daphne

AU - Slagboom, P. Eline

AU - Staal, Frank J. T.

AU - Reinders, Marcel J. T.

AU - Holstege, Henne

N1 - Funding Information: Stichting Diorapthe (VSM.14.04.14.02), Stichting VUmc Fonds and the Horstingstuit Foundation. The Leiden Longevity Study has received funding from the European Union’s Seventh Framework Programme (FP7/2007–2011) under grant agreement number 259679. This study was supported by the Netherlands Consortium for Healthy Ageing (grant 050-060-810), in the framework of the Netherlands Genomics Initiative, Netherlands Organization for Scientific Research (NWO); by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007). FJTS is funded in part by ZonMw E-RARE (113.302.002) and EU H2020 project RECOMB (755170). EvdA is funded by a personal grant of the Dutch Research Council (NWO; VENI: 09150161810095). Funding Information: Acknowledgements We thank W111 for her enthusiasm in study participation, for allowing repeated sample collection and agreeing to post mortem brain donation. Our acknowledgements also go out to her family, for their continuous support of this study. The 100-plus Study was supported by Stichting Alzheimer Nederland (WE09.2014-03),

PY - 2021/7

Y1 - 2021/7

UR - https://www.scopus.com/pages/publications/85095997920

UR - https://www.ncbi.nlm.nih.gov/pubmed/33184493

U2 - 10.1038/s41375-020-01086-0

DO - 10.1038/s41375-020-01086-0

M3 - Article

C2 - 33184493

SN - 0887-6924

VL - 35

SP - 2125

EP - 2129

JO - Leukemia

JF - Leukemia

IS - 7

ER -

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

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