Dosimetry of iodine-123 iomazenil in humans

N. P. Verhoeff; E. Busemann Sokole; D. Hengst; J. B. Stubbs; E. A. van Royen

doi:10.1007/BF00176551

Dosimetry of iodine-123 iomazenil in humans

N. P. Verhoeff
, E. Busemann Sokole
, D. Hengst
, J. B. Stubbs
, E. A. van Royen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq

Original language	English
Pages (from-to)	580-584
Journal	European journal of nuclear medicine
Volume	20
Issue number	7
DOIs	https://doi.org/10.1007/BF00176551
Publication status	Published - 1993

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title = "Dosimetry of iodine-123 iomazenil in humans",

abstract = "The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq",

author = "Verhoeff, \{N. P.\} and \{Busemann Sokole\}, E. and D. Hengst and Stubbs, \{J. B.\} and \{van Royen\}, \{E. A.\}",

year = "1993",

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language = "English",

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T1 - Dosimetry of iodine-123 iomazenil in humans

AU - Verhoeff, N. P.

AU - Busemann Sokole, E.

AU - Hengst, D.

AU - Stubbs, J. B.

AU - van Royen, E. A.

PY - 1993

Y1 - 1993

N2 - The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq

AB - The distribution of the central benzodiazepine receptor specific ligand iodine-123 iomazenil was investigated in seven human adults from whole-body scans, blood samples and urine collected up to 24 h after injection. Using 12 source organs, the MIRD method was applied to calculate the absorbed radiation dose of the radioligand in various organs. The urinary bladder wall (0.15 mGy/MBq), lower large intestinal wall (0.071 mGy/MBq) testes (0.044 mGy/MBq) and upper large intestined wall (0.038 mGy/MBq) received the highest absorbed doses. The average effective dose equivalent of 123I-IBZM for adults was estimated to be 0.033 mSv/MBq

U2 - 10.1007/BF00176551

DO - 10.1007/BF00176551

M3 - Article

C2 - 8370378

SN - 0340-6997

VL - 20

SP - 580

EP - 584

JO - European journal of nuclear medicine

JF - European journal of nuclear medicine

IS - 7

ER -

Dosimetry of iodine-123 iomazenil in humans

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