Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study

J. Lavalaye; A. Sarlet; J. Booij; D. H. Linszen; L. Reneman; B. P. Gersons; E. A. van Royen

doi:10.1007/s002130000670

Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study

J. Lavalaye
, A. Sarlet
, J. Booij
, D. H. Linszen
, L. Reneman
, B. P. Gersons
, E. A. van Royen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

RATIONALE: Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. OBJECTIVE: To evaluate dopamine transporter density in the striatum in patients with tardive dyskinesia. METHODS: Striatal [123I]FP-CIT binding was measured with SPECT in seven schizophrenic patients with tardive dyskinesia and eight healthy controls. RESULTS: No significant difference was found between striatal [123I]FP-CIT binding ratios in patients with tardive dyskinesia and controls. CONCLUSIONS: This preliminary study indicates no change in striatal dopamine transporter density in schizophrenic patients with tardive dyskinesia. This finding does not support the hypothesis that tardive dyskinesia is caused by dopaminergic cell loss

Original language	English
Pages (from-to)	107-109
Journal	Psychopharmacology
Volume	155
Issue number	1
DOIs	https://doi.org/10.1007/s002130000670
Publication status	Published - 2001

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title = "Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study",

abstract = "RATIONALE: Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. OBJECTIVE: To evaluate dopamine transporter density in the striatum in patients with tardive dyskinesia. METHODS: Striatal [123I]FP-CIT binding was measured with SPECT in seven schizophrenic patients with tardive dyskinesia and eight healthy controls. RESULTS: No significant difference was found between striatal [123I]FP-CIT binding ratios in patients with tardive dyskinesia and controls. CONCLUSIONS: This preliminary study indicates no change in striatal dopamine transporter density in schizophrenic patients with tardive dyskinesia. This finding does not support the hypothesis that tardive dyskinesia is caused by dopaminergic cell loss",

author = "J. Lavalaye and A. Sarlet and J. Booij and Linszen, \{D. H.\} and L. Reneman and Gersons, \{B. P.\} and \{van Royen\}, \{E. A.\}",

year = "2001",

doi = "10.1007/s002130000670",

language = "English",

volume = "155",

pages = "107--109",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer Verlag",

number = "1",

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TY - JOUR

T1 - Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study

AU - Lavalaye, J.

AU - Sarlet, A.

AU - Booij, J.

AU - Linszen, D. H.

AU - Reneman, L.

AU - Gersons, B. P.

AU - van Royen, E. A.

PY - 2001

Y1 - 2001

N2 - RATIONALE: Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. OBJECTIVE: To evaluate dopamine transporter density in the striatum in patients with tardive dyskinesia. METHODS: Striatal [123I]FP-CIT binding was measured with SPECT in seven schizophrenic patients with tardive dyskinesia and eight healthy controls. RESULTS: No significant difference was found between striatal [123I]FP-CIT binding ratios in patients with tardive dyskinesia and controls. CONCLUSIONS: This preliminary study indicates no change in striatal dopamine transporter density in schizophrenic patients with tardive dyskinesia. This finding does not support the hypothesis that tardive dyskinesia is caused by dopaminergic cell loss

AB - RATIONALE: Tardive dyskinesia occurs frequently in schizophrenic patients chronically treated with classical antipsychotic medication. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. OBJECTIVE: To evaluate dopamine transporter density in the striatum in patients with tardive dyskinesia. METHODS: Striatal [123I]FP-CIT binding was measured with SPECT in seven schizophrenic patients with tardive dyskinesia and eight healthy controls. RESULTS: No significant difference was found between striatal [123I]FP-CIT binding ratios in patients with tardive dyskinesia and controls. CONCLUSIONS: This preliminary study indicates no change in striatal dopamine transporter density in schizophrenic patients with tardive dyskinesia. This finding does not support the hypothesis that tardive dyskinesia is caused by dopaminergic cell loss

U2 - 10.1007/s002130000670

DO - 10.1007/s002130000670

M3 - Article

C2 - 11374328

SN - 0033-3158

VL - 155

SP - 107

EP - 109

JO - Psychopharmacology

JF - Psychopharmacology

IS - 1

ER -

Dopamine transporter density in patients with tardive dyskinesia: a single photon emission computed tomography study

Abstract

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