DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites

H. A. Westerbeek; W. J. Mooi; C. Begg; M. Dessing; A. J. M. Balm

doi:10.1007/BF00183488

DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites

H. A. Westerbeek
, W. J. Mooi
, C. Begg
, M. Dessing
, A. J. M. Balm^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements. © 1992 Springer-Verlag.

Original language	English
Pages (from-to)	140-143
Journal	European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS)
Volume	249
Issue number	3
DOIs	https://doi.org/10.1007/BF00183488
Publication status	Published - May 1992
Externally published	Yes

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10.1007/BF00183488

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Westerbeek, H. A., Mooi, W. J., Begg, C., Dessing, M., & Balm, A. J. M. (1992). DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), 249(3), 140-143. https://doi.org/10.1007/BF00183488

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title = "DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites",

abstract = "Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements. {\textcopyright} 1992 Springer-Verlag.",

author = "Westerbeek, \{H. A.\} and Mooi, \{W. J.\} and C. Begg and M. Dessing and Balm, \{A. J. M.\}",

year = "1992",

month = may,

doi = "10.1007/BF00183488",

language = "English",

volume = "249",

pages = "140--143",

journal = "European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS)",

issn = "0937-4477",

publisher = "Springer Verlag",

number = "3",

}

Westerbeek, HA, Mooi, WJ, Begg, C, Dessing, M & Balm, AJM 1992, 'DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites', European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), vol. 249, no. 3, pp. 140-143. https://doi.org/10.1007/BF00183488

DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites. / Westerbeek, H. A.; Mooi, W. J.; Begg, C. et al.
In: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), Vol. 249, No. 3, 05.1992, p. 140-143.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - DNA-flow cytometry of head and neck carcinoma

T2 - the importance of uniform tissue sampling and tumor sites

AU - Westerbeek, H. A.

AU - Mooi, W. J.

AU - Begg, C.

AU - Dessing, M.

AU - Balm, A. J. M.

PY - 1992/5

Y1 - 1992/5

N2 - Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements. © 1992 Springer-Verlag.

AB - Flow cytometric DNA ploidy measurements using deparaffinized tumor specimens were performed on 46 squamous cell carcinomas of the head and neck, including 22 carcinomas of the oropharynx, 18 carcinomas of the larynx and six carcinomas of the oral cavity. Aneuploidy was found in 14 of these tumors with carcinomas of the larynx and oral cavity showing almost equal percentages of DNA aneuploidy (10/18 and 3/6, respectively). In contrast, only 1 of the oropharyngeal carcinomas was aneuploid. Accurate microscopy-controlled sampling of tumor tissue from the histological tissue blocks was found to be mandatory in order to obtain reliable ploidy measurements. © 1992 Springer-Verlag.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/1642865

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DO - 10.1007/BF00183488

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SN - 0937-4477

VL - 249

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EP - 143

JO - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS)

JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS)

IS - 3

ER -

DNA-flow cytometry of head and neck carcinoma: the importance of uniform tissue sampling and tumor sites

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