Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Hester N. Blufpand; Nicole Hes; Arend Bökenkamp; Marianne D. van de Wetering; Gertjan J. L. Kaspers

doi:10.1002/pbc.24572

Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Hester N. Blufpand
, Nicole Hes
, Arend Bökenkamp
, Marianne D. van de Wetering
, Gertjan J. L. Kaspers

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337-344. © 2013 Wiley Periodicals, Inc

Original language	English
Pages (from-to)	337-344
Journal	Pediatric blood & cancer
Volume	61
Issue number	2
DOIs	https://doi.org/10.1002/pbc.24572
Publication status	Published - 2014

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SDG 3 Good Health and Well-being

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10.1002/pbc.24572

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title = "Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization",

abstract = "Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337-344. {\textcopyright} 2013 Wiley Periodicals, Inc",

author = "Blufpand, \{Hester N.\} and Nicole Hes and Arend B{\"o}kenkamp and \{van de Wetering\}, \{Marianne D.\} and Kaspers, \{Gertjan J. L.\}",

year = "2014",

doi = "10.1002/pbc.24572",

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T1 - Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

AU - Blufpand, Hester N.

AU - Hes, Nicole

AU - Bökenkamp, Arend

AU - van de Wetering, Marianne D.

AU - Kaspers, Gertjan J. L.

PY - 2014

Y1 - 2014

N2 - Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337-344. © 2013 Wiley Periodicals, Inc

AB - Despite changes in survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. To provide cutting-edge care for children with cancer oncologist must be familiar with their nephrotoxic potential. Careful monitoring of renal function during treatment is therefore indicated. Well-defined guidelines for this are lacking. We reviewed current DCOG protocols and showed that monitoring of renal function during treatment varies widely between protocols. In some protocols recommended renal function measures are inappropriate given the chemotherapy prescribed. Advices on dose modifications in case of renal dysfunction also vary, even with comparable regimens. These differences are unwanted and call for standardization. Pediatr Blood Cancer 2014;61:337-344. © 2013 Wiley Periodicals, Inc

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DO - 10.1002/pbc.24572

M3 - Review article

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EP - 344

JO - Pediatric blood & cancer

JF - Pediatric blood & cancer

IS - 2

ER -

Diversity in renal function monitoring and dose modifications during treatment for childhood cancer: A call for standardization

Abstract

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