Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis

Lizeth Y. F. Haveman; Cornelis A. J. Broersen; Danielle J. Vugts; Albert D. Windhorst

doi:10.1039/d5cc03503a

Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis

Lizeth Y. F. Haveman^*
, Cornelis A. J. Broersen
, Danielle J. Vugts
, Albert D. Windhorst

^*Corresponding author for this work

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2%.

Original language	English
Pages (from-to)	19505-19508
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	61
Issue number	98
DOIs	https://doi.org/10.1039/d5cc03503a
Publication status	Published - 21 Dec 2025

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title = "Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis",

abstract = "This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40\% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2\%.",

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AU - Haveman, Lizeth Y. F.

AU - Broersen, Cornelis A. J.

AU - Vugts, Danielle J.

AU - Windhorst, Albert D.

PY - 2025/12/21

Y1 - 2025/12/21

N2 - This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2%.

AB - This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2%.

UR - https://www.scopus.com/pages/publications/105024021770

U2 - 10.1039/d5cc03503a

DO - 10.1039/d5cc03503a

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EP - 19508

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 98

ER -

Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis

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