Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

Elisabeth Bergers; Joost C.J. Bot; Paul van der Valk; Jonas A. Castelijns; Geert J.Lycklama A. Nijeholt; Wouter Kamphorst; Chris H. Polman; Erwin L.A. Blezer; Klaas Nicolay; Rivka Ravid; Frederik Barkhof

doi:10.1002/ana.10170

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

Elisabeth Bergers^*
, Joost C.J. Bot
, Paul van der Valk
, Jonas A. Castelijns
, Geert J.Lycklama A. Nijeholt
, Wouter Kamphorst
, Chris H. Polman
, Erwin L.A. Blezer
, Klaas Nicolay
, Rivka Ravid
, Frederik Barkhof

^*Corresponding author for this work

MR Center for MS Research
Amsterdam UMC - Vrije Universiteit Amsterdam
Department of Radiology
Vrije Universiteit Amsterdam
Department of Pathology
Amsterdam UMC - Vrije Universiteit Amsterdam, Department of Neurology
Utrecht University
Netherlands Institute for Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

Original language	English
Pages (from-to)	652-656
Number of pages	5
Journal	Annals of neurology
Volume	51
Issue number	5
DOIs	https://doi.org/10.1002/ana.10170
Publication status	Published - 6 May 2002

Access to Document

10.1002/ana.10170

Fingerprint

Dive into the research topics of 'Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology'. Together they form a unique fingerprint.

Cite this

Bergers, E., Bot, J. C. J., van der Valk, P., Castelijns, J. A., Nijeholt, G. J. L. A., Kamphorst, W., Polman, C. H., Blezer, E. L. A., Nicolay, K., Ravid, R., & Barkhof, F. (2002). Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology. Annals of neurology, 51(5), 652-656. https://doi.org/10.1002/ana.10170

@article{34e696a3495747eea9921a7dfe5d315a,

title = "Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology",

abstract = "In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.",

author = "Elisabeth Bergers and Bot, \{Joost C.J.\} and \{van der Valk\}, Paul and Castelijns, \{Jonas A.\} and Nijeholt, \{Geert J.Lycklama A.\} and Wouter Kamphorst and Polman, \{Chris H.\} and Blezer, \{Erwin L.A.\} and Klaas Nicolay and Rivka Ravid and Frederik Barkhof",

year = "2002",

month = may,

day = "6",

doi = "10.1002/ana.10170",

language = "English",

volume = "51",

pages = "652--656",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "5",

}

Bergers, E, Bot, JCJ, van der Valk, P, Castelijns, JA, Nijeholt, GJLA, Kamphorst, W, Polman, CH, Blezer, ELA, Nicolay, K, Ravid, R & Barkhof, F 2002, 'Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology', Annals of neurology, vol. 51, no. 5, pp. 652-656. https://doi.org/10.1002/ana.10170

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology. / Bergers, Elisabeth; Bot, Joost C.J.; van der Valk, Paul et al.
In: Annals of neurology, Vol. 51, No. 5, 06.05.2002, p. 652-656.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Diffuse signal abnormalities in the spinal cord in multiple sclerosis

T2 - Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

AU - Bergers, Elisabeth

AU - Bot, Joost C.J.

AU - van der Valk, Paul

AU - Castelijns, Jonas A.

AU - Nijeholt, Geert J.Lycklama A.

AU - Kamphorst, Wouter

AU - Polman, Chris H.

AU - Blezer, Erwin L.A.

AU - Nicolay, Klaas

AU - Ravid, Rivka

AU - Barkhof, Frederik

PY - 2002/5/6

Y1 - 2002/5/6

N2 - In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

AB - In this study, we compared direct postmortem in situ (whole-corpse) sagittal spinal cord magnetic resonance imaging (1.5T) of 7 multiple sclerosis cases with targeted high-resolution in vitro axial magnetic resonance imaging (4.7T) and histopathology. On sagittal in situ magnetic resonance imaging, 1 case had a normal spinal cord, 2 had only focal lesions, 3 had a combination of focal and diffuse abnormalities, and 1 had only diffuse abnormalities. All spinal cords showed abnormalities on high-resolution magnetic resonance imaging and histopathology, confirming the existence of diffuse cord changes as genuine multiple sclerosis-related abnormalities while highlighting the limited resolution of in vivo magnetic resonance imaging.

UR - https://www.scopus.com/pages/publications/0036224681

U2 - 10.1002/ana.10170

DO - 10.1002/ana.10170

M3 - Article

C2 - 12112117

AN - SCOPUS:0036224681

SN - 0364-5134

VL - 51

SP - 652

EP - 656

JO - Annals of neurology

JF - Annals of neurology

IS - 5

ER -

Diffuse signal abnormalities in the spinal cord in multiple sclerosis: Direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology

Abstract

Access to Document

Other files and links

Fingerprint

Cite this