Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria

Le Thi Minh Vien; Manal Abuoun; Victoria Morrison; Nicholas Thomson; James I. Campbell; Martin J. Woodward; Nguyen van Vinh Chau; Jeremy Farrar; Constance Schultsz; Stephen Baker

doi:10.1128/AAC.01200-10

Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria

Le Thi Minh Vien
, Manal Abuoun
, Victoria Morrison
, Nicholas Thomson
, James I. Campbell
, Martin J. Woodward
, Nguyen van Vinh Chau
, Jeremy Farrar
, Constance Schultsz
, Stephen Baker

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The qnrS1 gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of qnrS1 plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of qnrS1 plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments

Original language	English
Pages (from-to)	1798-1802
Journal	Antimicrobial agents and chemotherapy
Volume	55
Issue number	4
DOIs	https://doi.org/10.1128/AAC.01200-10
Publication status	Published - 2011

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Vien, L. T. M., Abuoun, M., Morrison, V., Thomson, N., Campbell, J. I., Woodward, M. J., van Vinh Chau, N., Farrar, J., Schultsz, C., & Baker, S. (2011). Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria. Antimicrobial agents and chemotherapy, 55(4), 1798-1802. https://doi.org/10.1128/AAC.01200-10

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abstract = "The qnrS1 gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of qnrS1 plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of qnrS1 plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments",

author = "Vien, \{Le Thi Minh\} and Manal Abuoun and Victoria Morrison and Nicholas Thomson and Campbell, \{James I.\} and Woodward, \{Martin J.\} and \{van Vinh Chau\}, Nguyen and Jeremy Farrar and Constance Schultsz and Stephen Baker",

year = "2011",

doi = "10.1128/AAC.01200-10",

language = "English",

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Vien, LTM, Abuoun, M, Morrison, V, Thomson, N, Campbell, JI, Woodward, MJ, van Vinh Chau, N, Farrar, J, Schultsz, C & Baker, S 2011, 'Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria', Antimicrobial agents and chemotherapy, vol. 55, no. 4, pp. 1798-1802. https://doi.org/10.1128/AAC.01200-10

TY - JOUR

T1 - Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria

AU - Vien, Le Thi Minh

AU - Abuoun, Manal

AU - Morrison, Victoria

AU - Thomson, Nicholas

AU - Campbell, James I.

AU - Woodward, Martin J.

AU - van Vinh Chau, Nguyen

AU - Farrar, Jeremy

AU - Schultsz, Constance

AU - Baker, Stephen

PY - 2011

Y1 - 2011

N2 - The qnrS1 gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of qnrS1 plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of qnrS1 plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments

AB - The qnrS1 gene induces reduced susceptibility to fluoroquinolones in enterobacteria. We investigated the structure, antimicrobial susceptibility phenotype, and antimicrobial resistance gene characteristics of qnrS1 plasmids from hospitalized patients and community controls in southern Vietnam. We found that the antimicrobial susceptibilities, resistance gene characteristics, and plasmid structures of qnrS1 plasmids from the hospital differed from those from the community. Our data imply that the characteristics of the two plasmid groups are indicative of distinct selective pressures in the differing environments

U2 - 10.1128/AAC.01200-10

DO - 10.1128/AAC.01200-10

M3 - Article

C2 - 21282449

SN - 0066-4804

VL - 55

SP - 1798

EP - 1802

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

Differential Phenotypic and Genotypic Characteristics of qnrS1-Harboring Plasmids Carried by Hospital and Community Commensal Enterobacteria

Abstract

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