TY - JOUR
T1 - Differences in Sex Distribution between Genetic and Sporadic Frontotemporal Dementia
AU - de Boer, Sterre C. M.
AU - Riedl, Lina
AU - van der Lee, Sven J.
AU - Otto, Markus
AU - Anderl-Straub, Sarah
AU - Landin-Romero, Ramon
AU - Sorrentino, Federica
AU - Fieldhouse, Jay L. P.
AU - Reus, Lianne M.
AU - Vacaflor, Blanca
AU - Halliday, Glenda
AU - Galimberti, Daniela
AU - Diehl-Schmid, Janine
AU - Ducharme, Simon
AU - Piguet, Olivier
AU - Pijnenburg, Yolande A. L.
N1 - Funding Information:
The German sites were supported by the JPND networks PreFrontAls, Moodmarker and Genfi-Prox, the German Federal Ministry of Education and Research (FTLDc 01GI1007A) The Australian cohort was supported in part by funding to ForeFront, a large collaborative research group dedicated to the study of frontotemporal dementia and motor neuron disease funded by the National Health and Medical Research Council of Australia (NHMRC) Program Grant (GNT1132524), Dementia Research Team Grant (GNT1095127), NHMRC-JPND JPco-fuND-2 (GNT1191407, and the ARC Centre of Excellence in Cognition and its Disorders (CE11000102).
Funding Information:
Dr. Ducharme receives salary funding from the Fonds de Recherche du Québec – Santé.
Publisher Copyright:
© 2021 - The authors. Published by IOS Press.
PY - 2021
Y1 - 2021
N2 - Background: Reported sex distributions differ between frontotemporal dementia (FTD) cohorts. Possible explanations are the evolving clinical criteria of FTD and its subtypes and the discovery of FTD causal genetic mutations that has resulted in varying demographics. Objective: Our aim was to determine the sex distribution of sporadic and genetic FTD cases and its subtypes in an international cohort. Methods: We included 910 patients with behavioral variant frontotemporal dementia (bvFTD; n = 654), non-fluent variant primary progressive aphasia (nfvPPA; n = 99), semantic variant primary progressive aphasia (svPPA; n = 117), and right temporal variant frontotemporal dementia (rtvFTD; n = 40). We compared sex distribution between genetic and sporadic FTD using χ2-tests. Results: The genetic FTD group consisted of 51.2% males, which did not differ from sporadic FTD (57.8% male, p = 0.08). In the sporadic bvFTD subgroup, males were predominant in contrast to genetic bvFTD (61.6% versus 52.9% males, p = 0.04). In the other clinical FTD subgroups, genetic cases were underrepresented and within the sporadic cases the sex distribution was somewhat equal. Conclusion: The higher male prevalence in sporadic bvFTD may provide important clues for its differential pathogenesis and warrants further research.
AB - Background: Reported sex distributions differ between frontotemporal dementia (FTD) cohorts. Possible explanations are the evolving clinical criteria of FTD and its subtypes and the discovery of FTD causal genetic mutations that has resulted in varying demographics. Objective: Our aim was to determine the sex distribution of sporadic and genetic FTD cases and its subtypes in an international cohort. Methods: We included 910 patients with behavioral variant frontotemporal dementia (bvFTD; n = 654), non-fluent variant primary progressive aphasia (nfvPPA; n = 99), semantic variant primary progressive aphasia (svPPA; n = 117), and right temporal variant frontotemporal dementia (rtvFTD; n = 40). We compared sex distribution between genetic and sporadic FTD using χ2-tests. Results: The genetic FTD group consisted of 51.2% males, which did not differ from sporadic FTD (57.8% male, p = 0.08). In the sporadic bvFTD subgroup, males were predominant in contrast to genetic bvFTD (61.6% versus 52.9% males, p = 0.04). In the other clinical FTD subgroups, genetic cases were underrepresented and within the sporadic cases the sex distribution was somewhat equal. Conclusion: The higher male prevalence in sporadic bvFTD may provide important clues for its differential pathogenesis and warrants further research.
KW - Behavioral variant frontotemporal dementia
KW - Genetic
KW - Non-fluent variant primary progressive aphasia
KW - Right temporal variant frontotemporal dementia
KW - Semantic variant primary progressive aphasia
KW - Sex differences
KW - Sex distribution
KW - Sporadic
UR - https://www.scopus.com/pages/publications/85120454696
UR - https://www.ncbi.nlm.nih.gov/pubmed/34633319
U2 - 10.3233/JAD-210688
DO - 10.3233/JAD-210688
M3 - Article
C2 - 34633319
SN - 1387-2877
VL - 84
SP - 1153
EP - 1161
JO - Journal of Alzheimer's disease : JAD
JF - Journal of Alzheimer's disease : JAD
IS - 3
ER -
SDG 3 Good Health and Well-being