Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction

Arnon P. Kater; Maikel P. Peppelenbosch; Dees P. M. Brandjes; Mika Lumbantobing

doi:10.1128/CDLI.9.6.1396-1397.2002

Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction

Arnon P. Kater
, Maikel P. Peppelenbosch
, Dees P. M. Brandjes
, Mika Lumbantobing

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation Of I-kappaB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin

Original language	English
Pages (from-to)	1396-1397
Journal	Clinical and diagnostic laboratory immunology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1128/CDLI.9.6.1396-1397.2002
Publication status	Published - 2002

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SDG 3 Good Health and Well-being

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10.1128/CDLI.9.6.1396-1397.2002

Cite this

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title = "Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction",

abstract = "Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation Of I-kappaB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin",

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AU - Brandjes, Dees P. M.

AU - Lumbantobing, Mika

PY - 2002

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AB - Warfarin, a widely prescribed drug for preventing thrombosis, is thought to act solely through inhibition of vitamin K-dependent coagulation factors. Low concentrations of warfarin inhibit interleukin-6 production and phosphorylation Of I-kappaB but not activation of p38 mitogen-activated protein kinase. Thus, warfarin inhibits inflammatory signal transduction, and this may contribute to clinical effects of warfarin

U2 - 10.1128/CDLI.9.6.1396-1397.2002

DO - 10.1128/CDLI.9.6.1396-1397.2002

M3 - Article

C2 - 12414784

SN - 1071-412X

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SP - 1396

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JO - Clinical and diagnostic laboratory immunology

JF - Clinical and diagnostic laboratory immunology

IS - 6

ER -

Dichotomal effect of the coumadin derivative warfarin on inflammatory signal transduction

Abstract

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