Dialysis dose in acute kidney injury: no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.

Claudio Ronco; Dinna Cruz; Helen Oudemans van Straaten; Patrick Honore; Andrew House; D. Bin; Noel Gibney

Dialysis dose in acute kidney injury: no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.

Claudio Ronco^*
, Dinna Cruz
, Helen Oudemans van Straaten
, Patrick Honore
, Andrew House
, D. Bin
, Noel Gibney

^*Corresponding author for this work

Azienda Sanitaria Ulss 6 Vicenza

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.

Original language	English
Number of pages	1
Journal	Critical care (London, England)
Volume	12
Issue number	5
Publication status	Published - 1 Jan 2008

Cite this

@article{a8012756515d4005913123839871e8f8,

title = "Dialysis dose in acute kidney injury: no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.",

abstract = "The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.",

author = "Claudio Ronco and Dinna Cruz and \{van Straaten\}, \{Helen Oudemans\} and Patrick Honore and Andrew House and D. Bin and Noel Gibney",

year = "2008",

month = jan,

day = "1",

language = "English",

volume = "12",

journal = "Critical care (London, England)",

issn = "1364-8535",

publisher = "BioMed Central Ltd.",

number = "5",

}

TY - JOUR

T1 - Dialysis dose in acute kidney injury

T2 - no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.

AU - Ronco, Claudio

AU - Cruz, Dinna

AU - van Straaten, Helen Oudemans

AU - Honore, Patrick

AU - House, Andrew

AU - Bin, D.

AU - Gibney, Noel

PY - 2008/1/1

Y1 - 2008/1/1

N2 - The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.

AB - The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.

UR - https://www.scopus.com/pages/publications/58449119706

M3 - Review article

C2 - 18983695

SN - 1364-8535

VL - 12

JO - Critical care (London, England)

JF - Critical care (London, England)

IS - 5

ER -

Dialysis dose in acute kidney injury: no time for therapeutic nihilism--a critical appraisal of the Acute Renal Failure Trial Network study.

Abstract

Other files and links

Fingerprint

Cite this