Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

Meike de Wit; Evelien Dekker; Manon Spaander; Monique van Leerdam; Veerle Coupe; Gerrit Meijer; Beatriz Carvalho

doi:10.1007/s10620-025-08919-x

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

Meike de Wit
, Evelien Dekker
, Manon Spaander
, Monique van Leerdam
, Veerle Coupe
, Gerrit Meijer
, Beatriz Carvalho^*

^*Corresponding author for this work

Netherlands Cancer Institute
Amsterdam UMC - University of Amsterdam
Erasmus University Rotterdam
Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

Original language	English
Pages (from-to)	1683-1693
Number of pages	11
Journal	Digestive diseases and sciences
Volume	70
Issue number	5
Early online date	2025
DOIs	https://doi.org/10.1007/s10620-025-08919-x
Publication status	Published - May 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomarker development
CRC screening
Fecal immunochemical test (FIT)
Multitarget fecal immunochemical test (mtFIT)

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title = "Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)",

abstract = "Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.",

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month = may,

doi = "10.1007/s10620-025-08919-x",

language = "English",

volume = "70",

pages = "1683--1693",

journal = "Digestive diseases and sciences",

issn = "0163-2116",

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}

TY - JOUR

T1 - Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

AU - de Wit, Meike

AU - Dekker, Evelien

AU - Spaander, Manon

AU - van Leerdam, Monique

AU - Coupe, Veerle

AU - Meijer, Gerrit

AU - Carvalho, Beatriz

PY - 2025/5

Y1 - 2025/5

N2 - Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

AB - Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

KW - Biomarker development

KW - CRC screening

KW - Fecal immunochemical test (FIT)

KW - Multitarget fecal immunochemical test (mtFIT)

UR - https://www.scopus.com/pages/publications/105002604335

U2 - 10.1007/s10620-025-08919-x

DO - 10.1007/s10620-025-08919-x

M3 - Article

C2 - 40232574

SN - 0163-2116

VL - 70

SP - 1683

EP - 1693

JO - Digestive diseases and sciences

JF - Digestive diseases and sciences

IS - 5

ER -

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

Abstract

UN SDGs

Keywords

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