Determinants of B cell selection in germinal centers: Implications for antibody responses and vaccine design

M. de Gast

Determinants of B cell selection in germinal centers: Implications for antibody responses and vaccine design

M. de Gast

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

Viruses such as HIV-1, Hepatitis C virus (HCV), and SARS-CoV-2 pose major global health challenges due to their rapid evolution. To develop effective vaccines, it is essential to understand the principles that govern how the immune system selects and refines B cells capable of producing broadly neutralizing antibodies. This thesis explores the determinants of B cell

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Universiteit van Amsterdam
Supervisors/Advisors	van Gils, Marit, Supervisor Sanders, Rogier, Supervisor Claireaux, Mathieu, Co-supervisor
Award date	25 Feb 2026
Print ISBNs	9789465371467
Publication status	Published - 2026

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https://hdl.handle.net/11245.1/20f56588-c86d-4756-97d6-ed65b831ed59

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title = "Determinants of B cell selection in germinal centers: Implications for antibody responses and vaccine design",

abstract = "Viruses such as HIV-1, Hepatitis C virus (HCV), and SARS-CoV-2 pose major global health challenges due to their rapid evolution. To develop effective vaccines, it is essential to understand the principles that govern how the immune system selects and refines B cells capable of producing broadly neutralizing antibodies. This thesis explores the determinants of B cell",

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T2 - Implications for antibody responses and vaccine design

AU - de Gast, M.

PY - 2026

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AB - Viruses such as HIV-1, Hepatitis C virus (HCV), and SARS-CoV-2 pose major global health challenges due to their rapid evolution. To develop effective vaccines, it is essential to understand the principles that govern how the immune system selects and refines B cells capable of producing broadly neutralizing antibodies. This thesis explores the determinants of B cell

M3 - Phd-Thesis - Research and graduation internal

SN - 9789465371467

ER -

Determinants of B cell selection in germinal centers: Implications for antibody responses and vaccine design

Abstract

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