TY - JOUR
T1 - Delirium bij herstart clozapine na korte onderbreking
AU - Benckhuijsen, J. A. W.
AU - Keet, I. P. M.
PY - 2007
Y1 - 2007
N2 - Extra care must be taken in treating patients with clozapine because of the serious side-effects. A 44-year-old man with schizophrenia developed delirium on two occasions immediately after restarting clozapine at the dosage he had previously tolerated well; the clozapine-free periods had lasted 2 and 10 days respectively. Because of this 're-challenge' it seems very likely that there is a causal relation between the direct resumption of treatment with clozapine and delirium. Even if clozapine treatment is interrupted for only a short time it is important that the 'new' course begins with a low dosage and is increased very cautiously until it reaches the former, tolerated level.
AB - Extra care must be taken in treating patients with clozapine because of the serious side-effects. A 44-year-old man with schizophrenia developed delirium on two occasions immediately after restarting clozapine at the dosage he had previously tolerated well; the clozapine-free periods had lasted 2 and 10 days respectively. Because of this 're-challenge' it seems very likely that there is a causal relation between the direct resumption of treatment with clozapine and delirium. Even if clozapine treatment is interrupted for only a short time it is important that the 'new' course begins with a low dosage and is increased very cautiously until it reaches the former, tolerated level.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548839617&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/17853376
M3 - Article
C2 - 17853376
SN - 0303-7339
VL - 49
SP - 661
EP - 665
JO - Tijdschrift voor psychiatrie
JF - Tijdschrift voor psychiatrie
IS - 9
ER -