TY - CHAP
T1 - Deep brain stimulation for obsessive-compulsive disorder
AU - Karaszewska, D.M.
PY - 2024
Y1 - 2024
N2 - The evidence on the techniques, targets, and clinical results of deep brain stimulation (DBS) in obsessive-compulsive disorder (OCD) is constantly evolving. The aim of this chapter is to provide an overview of the latest updates on clinical results of DBS in OCD, predictors of response, and the mechanisms of action. Overall, studies have shown a significant mean improvement in Yale-Brown Obsessive Compulsive Scale of approximately 47% (95% CI 40%–53%) across treatment-refractory OCD patients. Furthermore, the quality of life improved in the physical and psychological domains at all targets. Surgery-related serious adverse events (SAEs) are relatively rare (7.9%) and mostly transient. These include infection and intracranial hemorrhage. In order to improve implementation of DBS in clinical practice for treatment of OCD and psychiatric disorders in general, it is important to educate future clinicians about the effectiveness of DBS in OCD.
AB - The evidence on the techniques, targets, and clinical results of deep brain stimulation (DBS) in obsessive-compulsive disorder (OCD) is constantly evolving. The aim of this chapter is to provide an overview of the latest updates on clinical results of DBS in OCD, predictors of response, and the mechanisms of action. Overall, studies have shown a significant mean improvement in Yale-Brown Obsessive Compulsive Scale of approximately 47% (95% CI 40%–53%) across treatment-refractory OCD patients. Furthermore, the quality of life improved in the physical and psychological domains at all targets. Surgery-related serious adverse events (SAEs) are relatively rare (7.9%) and mostly transient. These include infection and intracranial hemorrhage. In order to improve implementation of DBS in clinical practice for treatment of OCD and psychiatric disorders in general, it is important to educate future clinicians about the effectiveness of DBS in OCD.
U2 - 10.1016/b978-0-443-18496-3.00018-5
DO - 10.1016/b978-0-443-18496-3.00018-5
M3 - Chapter
T3 - Interventional Psychiatry
BT - Interventional Psychiatry
ER -