DC-SIGN and LFA-1: a battle for ligand

D. A. Bleijs; T. B. Geijtenbeek; C. G. Figdor; Y. van Kooyk

doi:10.1016/S1471-4906(01)01974-3

DC-SIGN and LFA-1: a battle for ligand

D. A. Bleijs
, T. B. Geijtenbeek
, C. G. Figdor
, Y. van Kooyk

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

Original language	English
Pages (from-to)	457-463
Journal	Trends in immunology
Volume	22
Issue number	8
DOIs	https://doi.org/10.1016/S1471-4906(01)01974-3
Publication status	Published - 2001

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title = "DC-SIGN and LFA-1: a battle for ligand",

abstract = "The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity",

author = "Bleijs, \{D. A.\} and Geijtenbeek, \{T. B.\} and Figdor, \{C. G.\} and \{van Kooyk\}, Y.",

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T1 - DC-SIGN and LFA-1: a battle for ligand

AU - Bleijs, D. A.

AU - Geijtenbeek, T. B.

AU - Figdor, C. G.

AU - van Kooyk, Y.

PY - 2001

Y1 - 2001

N2 - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

AB - The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity

U2 - 10.1016/S1471-4906(01)01974-3

DO - 10.1016/S1471-4906(01)01974-3

M3 - Review article

C2 - 11473836

SN - 1471-4906

VL - 22

SP - 457

EP - 463

JO - Trends in immunology

JF - Trends in immunology

IS - 8

ER -

DC-SIGN and LFA-1: a battle for ligand

Abstract

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