Cytokine specificity in macrophages: JAK-STAT and beyond

Josje M A Huisman; Alexandra Drakaki; Thomas Decker; Marten A Hoeksema

Cytokine specificity in macrophages: JAK-STAT and beyond

Department of Medical Biochemistry
location AMC
The Netherlands
Amsterdam Cardiovascular Sciences Institute
University of Vienna

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.

Original language	English
Pages (from-to)	255-258
Number of pages	4
Journal	Trends in immunology
Volume	47
Issue number	4
Publication status	Published - Apr 2026

Keywords

JAK-STAT
cytokine-specificity paradox
enhancers
macrophages
transcription factors

Cite this

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title = "Cytokine specificity in macrophages: JAK-STAT and beyond",

abstract = "Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.",

keywords = "JAK-STAT, cytokine-specificity paradox, enhancers, macrophages, transcription factors",

author = "Huisman, \{Josje M A\} and Alexandra Drakaki and Thomas Decker and Hoeksema, \{Marten A\}",

note = "Publisher Copyright: {\textcopyright} 2026 The Authors",

year = "2026",

month = apr,

language = "English",

volume = "47",

pages = "255--258",

journal = "Trends in immunology",

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T1 - Cytokine specificity in macrophages

T2 - JAK-STAT and beyond

AU - Huisman, Josje M A

AU - Drakaki, Alexandra

AU - Decker, Thomas

AU - Hoeksema, Marten A

PY - 2026/4

Y1 - 2026/4

N2 - Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.

AB - Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.

KW - JAK-STAT

KW - cytokine-specificity paradox

KW - enhancers

KW - macrophages

KW - transcription factors

UR - https://www.scopus.com/pages/publications/105031565705

M3 - Review article

C2 - 41763992

SN - 1471-4906

VL - 47

SP - 255

EP - 258

JO - Trends in immunology

JF - Trends in immunology

IS - 4

ER -

Cytokine specificity in macrophages: JAK-STAT and beyond

Abstract

Keywords

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