Cutane geneesmiddelenreacties

Cutaneous drug reactions are frequent. In patients using multiple drugs the identification of the culprit drug often is difficult. Indications for a causal relationship between a specific drug and the cutaneous reaction are: a known side effect, a clear relation between drug dose and reaction or between start of a new drug and the cutaneous reaction, positive dechallenge and positive rechallenge. No valid diagnostic procedures exist for the diagnosis of non-allergic drug reactions. When a type I or IV allergic drug reaction is suspected skin tests (percutaneous, intracutaneous or epicutaneous) can be performed. In type I allergic reactions a "window of anergy" lasting approximately 6 weeks exist, so skin tests should be performed after this period.