CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Marta del Campo; Carlos Quesada; Lisa Vermunt; Carel F. W. Peeters; Yanaika S. Hok-A-Hin; Calvin Trieu; Anouk den Braber; Inge M. W. Verberk; Pieter J. Visser; Betty M. Tijms; Wiesje M. van der Flier; Charlotte E. Teunissen

doi:10.1186/s13024-024-00767-z

CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Amsterdam UMC
Pasqual Maragall Foundation
Hospital del Mar
CEU Universities
Technical University of Madrid
Vrije Universiteit Amsterdam
Wageningen University & Research
Amsterdam UMC - Vrije Universiteit Amsterdam

Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Abstract

This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

Original language	English
Article number	82
Pages (from-to)	82
Journal	MOLECULAR NEURODEGENERATION
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13024-024-00767-z
Publication status	Published - Dec 2024

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Csf-proteins-of-inflammation-proteolysis-and-lipid-transport-define-preclinical-ad-and-progression-to-ad-dementia-in-co.pdfFinal published version, 5.02 MBLicence: CC BY

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del Campo, M., Quesada, C., Vermunt, L., Peeters, C. F. W., Hok-A-Hin, Y. S., Trieu, C., Braber, A. D., Verberk, I. M. W., Visser, P. J., Tijms, B. M., van der Flier, W. M., & Teunissen, C. E. (2024). CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals. MOLECULAR NEURODEGENERATION, 19(1), 82. Article 82. https://doi.org/10.1186/s13024-024-00767-z

@article{e98b7a4f67fa494fa108c89650313d0c,

title = "CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals",

abstract = "This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.",

author = "\{del Campo\}, Marta and Carlos Quesada and Lisa Vermunt and Peeters, \{Carel F. W.\} and Hok-A-Hin, \{Yanaika S.\} and Calvin Trieu and Braber, \{Anouk den\} and Verberk, \{Inge M. W.\} and Visser, \{Pieter J.\} and Tijms, \{Betty M.\} and \{van der Flier\}, \{Wiesje M.\} and Teunissen, \{Charlotte E.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1186/s13024-024-00767-z",

language = "English",

volume = "19",

pages = "82",

journal = "MOLECULAR NEURODEGENERATION",

issn = "1750-1326",

publisher = "BioMed Central Ltd.",

number = "1",

}

del Campo, M, Quesada, C, Vermunt, L, Peeters, CFW, Hok-A-Hin, YS , Trieu, C , Braber, AD , Verberk, IMW , Visser, PJ , Tijms, BM , van der Flier, WM & Teunissen, CE 2024, 'CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals', MOLECULAR NEURODEGENERATION, vol. 19, no. 1, 82, pp. 82. https://doi.org/10.1186/s13024-024-00767-z

TY - JOUR

T1 - CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

AU - del Campo, Marta

AU - Quesada, Carlos

AU - Vermunt, Lisa

AU - Peeters, Carel F. W.

AU - Hok-A-Hin, Yanaika S.

AU - Trieu, Calvin

AU - Braber, Anouk den

AU - Verberk, Inge M. W.

AU - Visser, Pieter J.

AU - Tijms, Betty M.

AU - van der Flier, Wiesje M.

AU - Teunissen, Charlotte E.

PY - 2024/12

Y1 - 2024/12

N2 - This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

AB - This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical progression to AD with high accuracy; some of these CSF proteins related to immune function, neurotrophic processes, energy metabolism and endolysosomal functioning (e.g., ITGB2, CLEC5A, IGFBP-1, CST3) changed before amyloid positivity is established.

UR - https://www.scopus.com/pages/publications/85209475929

U2 - 10.1186/s13024-024-00767-z

DO - 10.1186/s13024-024-00767-z

M3 - Comment/Letter to the editor

C2 - 39523360

SN - 1750-1326

VL - 19

SP - 82

JO - MOLECULAR NEURODEGENERATION

JF - MOLECULAR NEURODEGENERATION

IS - 1

M1 - 82

ER -

CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

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Additional file 2 of CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Additional file 2 of CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

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CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Abstract

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Additional file 3 of CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Additional file 2 of CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

Additional file 2 of CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

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