Correlation Between HIV-1 Seropositivity and Prevalence of a gamma-Secretase Polymorphism in Two Distinct Ethnic Populations

Karen M. J. van Loo; Jessica E. Van Schijndel; Martine Van Zweeden; Daniëlle van Manen; Mieke D. Trip; Desiree C. Petersen; Hanneke Schuitemaker; Vanessa M. Hayes; Gerard J. M. Martens

doi:10.1002/jmv.21601

Correlation Between HIV-1 Seropositivity and Prevalence of a gamma-Secretase Polymorphism in Two Distinct Ethnic Populations

Karen M. J. van Loo
, Jessica E. Van Schijndel
, Martine Van Zweeden
, Daniëlle van Manen
, Mieke D. Trip
, Desiree C. Petersen
, Hanneke Schuitemaker
, Vanessa M. Hayes
, Gerard J. M. Martens

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Susceptibility for human immunodeficiency virus type 1 (HIV-1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the gamma-secretase pathway may be associated with an individual's susceptibility to infection. A functional single-nucleotide polymorphism (SNP) in the gamma-secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV-1 infection. The SNP showed a tendency for association with HIV-1 infection in a Xhosa indigenous South African Bantu study (P=0.087), and associated significantly in a Caucasian Dutch study (P=0.049). Together, the results suggest a role for the gamma-secretase pathway in susceptibility to HIV-1 infection. J. Med. Virol. 81:18471851, 2009. (C) 2009 Wiley-Liss, Inc

Original language	English
Pages (from-to)	1847-1851
Journal	Journal of medical virology
Volume	81
Issue number	11
DOIs	https://doi.org/10.1002/jmv.21601
Publication status	Published - 2009

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SDG 3 Good Health and Well-being

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10.1002/jmv.21601

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van Loo, K. M. J., Van Schijndel, J. E., Van Zweeden, M., van Manen, D., Trip, M. D., Petersen, D. C., Schuitemaker, H., Hayes, V. M., & Martens, G. J. M. (2009). Correlation Between HIV-1 Seropositivity and Prevalence of a gamma-Secretase Polymorphism in Two Distinct Ethnic Populations. Journal of medical virology, 81(11), 1847-1851. https://doi.org/10.1002/jmv.21601

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title = "Correlation Between HIV-1 Seropositivity and Prevalence of a gamma-Secretase Polymorphism in Two Distinct Ethnic Populations",

abstract = "Susceptibility for human immunodeficiency virus type 1 (HIV-1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the gamma-secretase pathway may be associated with an individual's susceptibility to infection. A functional single-nucleotide polymorphism (SNP) in the gamma-secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV-1 infection. The SNP showed a tendency for association with HIV-1 infection in a Xhosa indigenous South African Bantu study (P=0.087), and associated significantly in a Caucasian Dutch study (P=0.049). Together, the results suggest a role for the gamma-secretase pathway in susceptibility to HIV-1 infection. J. Med. Virol. 81:18471851, 2009. (C) 2009 Wiley-Liss, Inc",

author = "\{van Loo\}, \{Karen M. J.\} and \{Van Schijndel\}, \{Jessica E.\} and \{Van Zweeden\}, Martine and \{van Manen\}, Dani{\"e}lle and Trip, \{Mieke D.\} and Petersen, \{Desiree C.\} and Hanneke Schuitemaker and Hayes, \{Vanessa M.\} and Martens, \{Gerard J. M.\}",

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AU - van Loo, Karen M. J.

AU - Van Schijndel, Jessica E.

AU - Van Zweeden, Martine

AU - van Manen, Daniëlle

AU - Trip, Mieke D.

AU - Petersen, Desiree C.

AU - Schuitemaker, Hanneke

AU - Hayes, Vanessa M.

AU - Martens, Gerard J. M.

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AB - Susceptibility for human immunodeficiency virus type 1 (HIV-1) infection may be influenced by host genetics. Recent findings with a Wistar rat model raised the possibility that the gamma-secretase pathway may be associated with an individual's susceptibility to infection. A functional single-nucleotide polymorphism (SNP) in the gamma-secretase component APH1B (Phe217Leu; rs1047552) was therefore analyzed for association with HIV-1 infection. The SNP showed a tendency for association with HIV-1 infection in a Xhosa indigenous South African Bantu study (P=0.087), and associated significantly in a Caucasian Dutch study (P=0.049). Together, the results suggest a role for the gamma-secretase pathway in susceptibility to HIV-1 infection. J. Med. Virol. 81:18471851, 2009. (C) 2009 Wiley-Liss, Inc

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JF - Journal of medical virology

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ER -

Correlation Between HIV-1 Seropositivity and Prevalence of a gamma-Secretase Polymorphism in Two Distinct Ethnic Populations

Abstract

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