TY - JOUR
T1 - Consensus-Based Technical Recommendations for Clinical Translation of Renal Phase Contrast MRI
AU - de Boer, Anneloes
AU - Villa, Giulia
AU - Bane, Octavia
AU - Bock, Michael
AU - Cox, Eleanor F.
AU - Dekkers, Ilona A.
AU - Eckerbom, Per
AU - Fernández-Seara, Maria A.
AU - Francis, Susan T.
AU - Haddock, Bryan
AU - Hall, Michael E.
AU - Hall Barrientos, Pauline
AU - Hermann, Ingo
AU - Hockings, Paul D.
AU - Lamb, Hildo J.
AU - Laustsen, Christoffer
AU - Lim, Ruth P.
AU - Morris, David M.
AU - Ringgaard, Steffen
AU - Serai, Suraj D.
AU - Sharma, Kanishka
AU - Sourbron, Steven
AU - Takehara, Yasuo
AU - Wentland, Andrew L.
AU - Wolf, Marcos
AU - Zöllner, Frank G.
AU - Nery, Fabio
AU - Caroli, Anna
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Background: Phase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool. Purpose: To build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies. Study Type: Systematic consensus process using a modified Delphi method. Population: Not applicable. Sequence Field/Strength: Renal fast gradient echo-based 2D PC-MRI. Assessment: An international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4–10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated. Statistical Tests: Consensus was defined as ≥75% unanimity in response, and a clear preference was defined as 60–74% agreement among the experts. Results: Among 60 statements, 57 (95%) achieved consensus after the second-round survey, while the remaining three showed a clear preference. Consensus statements resulted in specific recommendations for subject preparation, 2D renal PC-MRI data acquisition, processing, and reporting. Data Conclusion: These recommendations might promote a widespread adoption of renal PC-MRI, and may help foster the set-up of multicenter studies aimed at defining reference values and building larger and more definitive evidence, and will facilitate clinical translation of PC-MRI. Level of Evidence: 1. Technical Efficacy Stage: 1.
AB - Background: Phase-contrast (PC) MRI is a feasible and valid noninvasive technique to measure renal artery blood flow, showing potential to support diagnosis and monitoring of renal diseases. However, the variability in measured renal blood flow values across studies is large, most likely due to differences in PC-MRI acquisition and processing. Standardized acquisition and processing protocols are therefore needed to minimize this variability and maximize the potential of renal PC-MRI as a clinically useful tool. Purpose: To build technical recommendations for the acquisition, processing, and analysis of renal 2D PC-MRI data in human subjects to promote standardization of renal blood flow measurements and facilitate the comparability of results across scanners and in multicenter clinical studies. Study Type: Systematic consensus process using a modified Delphi method. Population: Not applicable. Sequence Field/Strength: Renal fast gradient echo-based 2D PC-MRI. Assessment: An international panel of 27 experts from Europe, the USA, Australia, and Japan with 6 (interquartile range 4–10) years of experience in 2D PC-MRI formulated consensus statements on renal 2D PC-MRI in two rounds of surveys. Starting from a recently published systematic review article, literature-based and data-driven statements regarding patient preparation, hardware, acquisition protocol, analysis steps, and data reporting were formulated. Statistical Tests: Consensus was defined as ≥75% unanimity in response, and a clear preference was defined as 60–74% agreement among the experts. Results: Among 60 statements, 57 (95%) achieved consensus after the second-round survey, while the remaining three showed a clear preference. Consensus statements resulted in specific recommendations for subject preparation, 2D renal PC-MRI data acquisition, processing, and reporting. Data Conclusion: These recommendations might promote a widespread adoption of renal PC-MRI, and may help foster the set-up of multicenter studies aimed at defining reference values and building larger and more definitive evidence, and will facilitate clinical translation of PC-MRI. Level of Evidence: 1. Technical Efficacy Stage: 1.
UR - https://www.scopus.com/pages/publications/85096705497
UR - https://www.ncbi.nlm.nih.gov/pubmed/33140551
U2 - 10.1002/jmri.27419
DO - 10.1002/jmri.27419
M3 - Article
C2 - 33140551
SN - 1053-1807
VL - 55
SP - 323
EP - 335
JO - Journal of magnetic resonance imaging
JF - Journal of magnetic resonance imaging
IS - 2
ER -