Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers

Hans L. Zaaijer; P. N. Lelie; C. M. J. E. Vandenbroucke-Grauls; M. Koot

doi:10.1046/j.1365-2893.2002.00342.x

Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers

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Abstract

Among 1081 persons testing positive for hepatitis B surface antigen, 106 (10%) tested positive for antibodies to surface antigen (anti-HBs) in the same blood sample. Thirty of these persons were studied in detail: seven tested positive for hepatitis B e-antigen, nine were apparently healthy blood donors, and in 14 chronic infection could be demonstrated in follow-up samples. Frozen samples of 14 persons were available for additional quantitative anti-HBs testing using another anti-HBs assay: three showed no anti-HBs reactivity, seven showed borderline anti-HBs levels (1-5 IU/L), and anti-HBs titres ranged from 23 to 66 IU/L in four HBsAg-positive persons, including an apparently healthy blood donor. Thus, after hepatitis B vaccination of medical personnel, presence of anti-HBs may erroneously suggest immunity, while in fact chronic infection with hepatitis B virus is present

Original language	English
Pages (from-to)	146-148
Journal	Journal of viral hepatitis
Volume	9
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2893.2002.00342.x
Publication status	Published - 2002

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10.1046/j.1365-2893.2002.00342.x

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title = "Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers",

abstract = "Among 1081 persons testing positive for hepatitis B surface antigen, 106 (10\%) tested positive for antibodies to surface antigen (anti-HBs) in the same blood sample. Thirty of these persons were studied in detail: seven tested positive for hepatitis B e-antigen, nine were apparently healthy blood donors, and in 14 chronic infection could be demonstrated in follow-up samples. Frozen samples of 14 persons were available for additional quantitative anti-HBs testing using another anti-HBs assay: three showed no anti-HBs reactivity, seven showed borderline anti-HBs levels (1-5 IU/L), and anti-HBs titres ranged from 23 to 66 IU/L in four HBsAg-positive persons, including an apparently healthy blood donor. Thus, after hepatitis B vaccination of medical personnel, presence of anti-HBs may erroneously suggest immunity, while in fact chronic infection with hepatitis B virus is present",

author = "Zaaijer, \{Hans L.\} and Lelie, \{P. N.\} and Vandenbroucke-Grauls, \{C. M. J. E.\} and M. Koot",

year = "2002",

doi = "10.1046/j.1365-2893.2002.00342.x",

language = "English",

volume = "9",

pages = "146--148",

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T1 - Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers

AU - Zaaijer, Hans L.

AU - Lelie, P. N.

AU - Vandenbroucke-Grauls, C. M. J. E.

AU - Koot, M.

PY - 2002

Y1 - 2002

N2 - Among 1081 persons testing positive for hepatitis B surface antigen, 106 (10%) tested positive for antibodies to surface antigen (anti-HBs) in the same blood sample. Thirty of these persons were studied in detail: seven tested positive for hepatitis B e-antigen, nine were apparently healthy blood donors, and in 14 chronic infection could be demonstrated in follow-up samples. Frozen samples of 14 persons were available for additional quantitative anti-HBs testing using another anti-HBs assay: three showed no anti-HBs reactivity, seven showed borderline anti-HBs levels (1-5 IU/L), and anti-HBs titres ranged from 23 to 66 IU/L in four HBsAg-positive persons, including an apparently healthy blood donor. Thus, after hepatitis B vaccination of medical personnel, presence of anti-HBs may erroneously suggest immunity, while in fact chronic infection with hepatitis B virus is present

AB - Among 1081 persons testing positive for hepatitis B surface antigen, 106 (10%) tested positive for antibodies to surface antigen (anti-HBs) in the same blood sample. Thirty of these persons were studied in detail: seven tested positive for hepatitis B e-antigen, nine were apparently healthy blood donors, and in 14 chronic infection could be demonstrated in follow-up samples. Frozen samples of 14 persons were available for additional quantitative anti-HBs testing using another anti-HBs assay: three showed no anti-HBs reactivity, seven showed borderline anti-HBs levels (1-5 IU/L), and anti-HBs titres ranged from 23 to 66 IU/L in four HBsAg-positive persons, including an apparently healthy blood donor. Thus, after hepatitis B vaccination of medical personnel, presence of anti-HBs may erroneously suggest immunity, while in fact chronic infection with hepatitis B virus is present

U2 - 10.1046/j.1365-2893.2002.00342.x

DO - 10.1046/j.1365-2893.2002.00342.x

M3 - Article

C2 - 11876798

SN - 1352-0504

VL - 9

SP - 146

EP - 148

JO - Journal of viral hepatitis

JF - Journal of viral hepatitis

IS - 2

ER -

Concurrence of hepatitis B surface antibodies and surface antigen: implications for postvaccination control of health care workers

Abstract

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