Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

W. A. van Gool; D. B. Schenk; P. A. Bolhuis

doi:10.1016/0304-3940(94)90677-7

Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

W. A. van Gool
, D. B. Schenk
, P. A. Bolhuis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Cerebral deposition of amyloid-beta protein (A beta) is central to the pathogenesis of Alzheimer's disease (AD). Increasing age is one of the few definitively established risk factors for this disease. The concentration of A beta was measured in cerebrospinal fluid (CSF) with a sensitive enzyme-linked immunosorbent assay in 18 adult neurological patients free from neurodegenerative disease. CSF A beta increased with age, yielding a significant correlation of 0.84. This observation suggests that increased levels of A beta in CSF may be an index of age-related changes in the processing of the amyloid-beta precursor protein resulting in an increased risk for AD

Original language	English
Pages (from-to)	122-124
Journal	Neuroscience letters
Volume	172
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90677-7
Publication status	Published - 1994

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title = "Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease",

abstract = "Cerebral deposition of amyloid-beta protein (A beta) is central to the pathogenesis of Alzheimer's disease (AD). Increasing age is one of the few definitively established risk factors for this disease. The concentration of A beta was measured in cerebrospinal fluid (CSF) with a sensitive enzyme-linked immunosorbent assay in 18 adult neurological patients free from neurodegenerative disease. CSF A beta increased with age, yielding a significant correlation of 0.84. This observation suggests that increased levels of A beta in CSF may be an index of age-related changes in the processing of the amyloid-beta precursor protein resulting in an increased risk for AD",

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AB - Cerebral deposition of amyloid-beta protein (A beta) is central to the pathogenesis of Alzheimer's disease (AD). Increasing age is one of the few definitively established risk factors for this disease. The concentration of A beta was measured in cerebrospinal fluid (CSF) with a sensitive enzyme-linked immunosorbent assay in 18 adult neurological patients free from neurodegenerative disease. CSF A beta increased with age, yielding a significant correlation of 0.84. This observation suggests that increased levels of A beta in CSF may be an index of age-related changes in the processing of the amyloid-beta precursor protein resulting in an increased risk for AD

U2 - 10.1016/0304-3940(94)90677-7

DO - 10.1016/0304-3940(94)90677-7

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SP - 122

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JO - Neuroscience letters

JF - Neuroscience letters

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ER -

Concentrations of amyloid-beta protein in cerebrospinal fluid increase with age in patients free from neurodegenerative disease

Abstract

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