TY - JOUR
T1 - Computer-aided diagnosis for optical diagnosis of diminutive colorectal polyps including sessile serrated lesions
T2 - a real-time comparison with screening endoscopists
AU - POLAR study group
AU - Houwen, Britt B. S. L.
AU - Hazewinkel, Yark
AU - Giotis, Ioannis
AU - Vleugels, Jasper L. A.
AU - Mostafavi, Nahid S.
AU - van Putten, Paul
AU - Fockens, Paul
AU - Dekker, Evelien
N1 - Funding Information:
ED received a research grant from Fujifilm, a consulting fee for medical advice from Olympus, Fujifilm, GI Supply, PAION, Ambu and CPP-FAP and a speakers' fee from Olympus, Roche, GI Supply, Norgine, Fujifilm and IPSEN. PF received research support from Boston Scientific and a consulting fee from Olympus and Cook Endoscopy. The remaining Authors declare that there is no conflict of interest.
Publisher Copyright:
© 2022 Georg Thieme Verlag. All rights reserved.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - Background: In this study, we aimed to compare the accuracy for optical diagnosis of diminutive colorectal polyps between a CADx system (POLAR system) and endoscopists during real-time colonoscopy, including sessile serrated lesions (SSLs). Patients and methods: We developed the POLAR system, capable of performing real-time characterization of diminutive colorectal polyps. For pre-training, the Microsoft-COCO dataset with non-polyp object images (300k) was used. For training, 8 hospitals prospectively collected 2.637 annotated images from 1.339 polyps (i.e. new publicly available POLAR database). For clinical validation, POLAR was tested during colonoscopy in fecal immunochemical test (FIT)-positive individuals, and compared with the performance of 20 endoscopists from 8 hospitals. Endoscopists were blinded to the POLAR outcome. Primary outcome was the comparison of accuracy in the optical diagnosis of diminutive colorectal polyps between POLAR and endoscopists (neoplastic [adenomas and SSLs] vs non-neoplastic [hyperplastic polyps]). Histopathology served as the reference standard. Results: During clinical validation, a total of 423 diminutive polyps detected in 194 FIT-positive individuals were included for analysis (300 adenomas, 41 SSLs, 82 hyperplastic polyps). POLAR distinguished neoplastic from non-neoplastic lesions with 79% accuracy, 89% sensitivity and 38% specificity. The endoscopists achieved 83% accuracy, 92% sensitivity, and 44% specificity. The optical diagnosis accuracy between POLAR and endoscopists was not significantly different (P=.10). The success rate for acquiring a histological prediction by POLAR was 98%. Conclusions: We have developed a CADx system that differentiated neoplastic from non-neoplastic diminutive polyps during endoscopy with an accuracy comparable to the accuracy of screening endoscopists, with near-perfect technical efficacy.
AB - Background: In this study, we aimed to compare the accuracy for optical diagnosis of diminutive colorectal polyps between a CADx system (POLAR system) and endoscopists during real-time colonoscopy, including sessile serrated lesions (SSLs). Patients and methods: We developed the POLAR system, capable of performing real-time characterization of diminutive colorectal polyps. For pre-training, the Microsoft-COCO dataset with non-polyp object images (300k) was used. For training, 8 hospitals prospectively collected 2.637 annotated images from 1.339 polyps (i.e. new publicly available POLAR database). For clinical validation, POLAR was tested during colonoscopy in fecal immunochemical test (FIT)-positive individuals, and compared with the performance of 20 endoscopists from 8 hospitals. Endoscopists were blinded to the POLAR outcome. Primary outcome was the comparison of accuracy in the optical diagnosis of diminutive colorectal polyps between POLAR and endoscopists (neoplastic [adenomas and SSLs] vs non-neoplastic [hyperplastic polyps]). Histopathology served as the reference standard. Results: During clinical validation, a total of 423 diminutive polyps detected in 194 FIT-positive individuals were included for analysis (300 adenomas, 41 SSLs, 82 hyperplastic polyps). POLAR distinguished neoplastic from non-neoplastic lesions with 79% accuracy, 89% sensitivity and 38% specificity. The endoscopists achieved 83% accuracy, 92% sensitivity, and 44% specificity. The optical diagnosis accuracy between POLAR and endoscopists was not significantly different (P=.10). The success rate for acquiring a histological prediction by POLAR was 98%. Conclusions: We have developed a CADx system that differentiated neoplastic from non-neoplastic diminutive polyps during endoscopy with an accuracy comparable to the accuracy of screening endoscopists, with near-perfect technical efficacy.
UR - https://www.scopus.com/pages/publications/85159687859
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166362440&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36623839
U2 - 10.1055/a-2009-3990
DO - 10.1055/a-2009-3990
M3 - Article
C2 - 36623839
SN - 0013-726X
VL - 55
SP - 756
EP - 765
JO - Endoscopy
JF - Endoscopy
IS - 8
ER -